Yusuf Hamied Department of Chemistry

Publications by Professor Steve Ley CBE FRS FMedSci

Accelerating spirocyclic polyketide synthesis using flow chemistry
S Newton, CF Carter, CM Pearson, L De C. Alves, H Lange, P Thansandote, SV Ley
Angewandte Chemie International Edition
(2014)
53
(doi: 10.1002/anie.201402056)
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns.
J Hartwig, JB Metternich, N Nikbin, A Kirschning, SV Ley
Organic & Biomolecular Chemistry
(2014)
12
(doi: 10.1039/c4ob00662c)
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
RJ Ingham, C Battilocchio, JM Hawkins, SV Ley
Beilstein Journal of Organic Chemistry
(2014)
10
(doi: 10.3762/bjoc.10.56)
Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide
C Battilocchio, JM Hawkins, SV Ley
Organic letters
(2014)
16
(doi: 10.1021/ol403591c)
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne
Chemistry A European Journal
(2014)
20
(doi: 10.1002/chem.201303736)
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
L Guetzoyan, RJ Ingham, N Nikbin, J Rossignol, M Wolling, M Baumert, NA Burgess-Brown, CM Strain-Damerell, L Shrestha, PE Brennan, O Fedorov, S Knapp, SV Ley
Medchemcomm
(2014)
5
(doi: 10.1039/c4md00007b)
Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium
G Rouquet, DC Blakemore, SV Ley
Chem. Commun.
(2014)
50
(doi: 10.1039/c4cc03766a)
Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts
RS Chorghade, C Battilocchio, SV Ley
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
247
Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry
KR Knudsen, M Ladlow, Z Bandpey, SV Ley
Journal of Flow Chemistry
(2014)
4
(doi: 10.1556/jfc-d-13-00033)
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
DM Allwood, DC Blakemore, AD Brown, SV Ley
The Journal of Organic Chemistry
(2013)
79
(doi: 10.1021/jo402526z)
Fragment-based hit identification: Thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt
Drug Discovery Today
(2013)
18
(doi: 10.1016/j.drudis.2013.07.011)
Abstract B96: Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
Molecular Cancer Therapeutics
(2013)
12
(doi: 10.1158/1535-7163.targ-13-b96)
An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.
M Baumann, IR Baxendale
Beilstein Journal of Organic Chemistry
(2013)
9
(doi: 10.3762/bjoc.9.265)
Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.
R Chorghade, C Battilocchio, JM Hawkins, SV Ley
Org Lett
(2013)
15
(doi: 10.1021/ol4027107)
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
Chemistry & biology
(2013)
20
(doi: 10.1016/j.chembiol.2013.09.012)
Flow‐Based, Cerium Oxide Enhanced, Low‐Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
C Battilocchio, BN Bhawal, R Chorghade, BJ Deadman, JM Hawkins, SV Ley
Israel Journal of Chemistry
(2013)
54
(doi: 10.1002/ijch.201300049)
Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen
PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley
Organic Process Research and Development
(2013)
17
(doi: 10.1021/op4001548)
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow
KA Roper, MB Berry, SV Ley
Beilstein Journal of Organic Chemistry
(2013)
9
(doi: 10.3762/bjoc.9.207)
Flow chemistry syntheses of natural products
JC Pastre, DL Browne, SV Ley
Chemical Society reviews
(2013)
42
(doi: 10.1039/c3cs60246j)
Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia
JC Pastre, DL Browne, M O’Brien, SV Ley
Organic Process Research and Development
(2013)
17
(doi: 10.1021/op400152r)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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