Yusuf Hamied Department of Chemistry

Publications by Professor Steve Ley CBE FRS FMedSci

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos
Science advances
(2016)
2
(doi: 10.1126/sciadv.1600760)
Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley
Organic Process Research & Development
(2016)
20
(doi: 10.1021/acs.oprd.6b00177)
The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B
S Fenner, ZE Wilson, SV Ley
Chemistry - A European Journal
(2016)
22
(doi: 10.1002/chem.201603157)
Flow Chemistry in Europe
V Hessel, SV Ley
Journal of Flow Chemistry
(2016)
6
(doi: 10.1556/1846.2016.22222)
Taming hazardous chemistry by continuous flow technology.
M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens
Chemical Society Reviews
(2016)
45
(doi: 10.1039/c5cs00902b)
A multicomponent approach for the preparation of homoallylic alcohols.
J-S Poh, S-H Lau, IG Dykes, DN Tran, C Battilocchio, SV Ley
Chem Sci
(2016)
7
(doi: 10.1039/c6sc02581a)
Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation
J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley
Organic & biomolecular chemistry
(2016)
14
(doi: 10.1039/c6ob00970k)
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex
CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley
Journal of medicinal chemistry
(2016)
59
(doi: 10.1021/acs.jmedchem.5b01997)
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley
ACS Sustainable Chemistry and Engineering
(2016)
4
(doi: 10.1021/acssuschemeng.6b00287)
Development of the industrial synthesis of vitamin A
GL Parker, LK Smith, IR Baxendale
Tetrahedron
(2016)
72
(doi: 10.1016/j.tet.2016.02.029)
The Generation of a Library of ­Bromodomain‐Containing Protein Modulators Expedited by Continuous Flow Synthesis
P Filipponi, IR Baxendale
European Journal of Organic Chemistry
(2016)
2016
(doi: 10.1002/ejoc.201600222)
Enabling Technologies for the Future of Chemical Synthesis.
DE Fitzpatrick, C Battilocchio, SV Ley
ACS Cent Sci
(2016)
2
(doi: 10.1021/acscentsci.6b00015)
Iterative reactions of transient boronic acids enable sequential C-C bond formation
C Battilocchio, F Feist, A Hafner, M Simon, DN Tran, DM Allwood, DC Blakemore, SV Ley
Nat Chem
(2016)
8
(doi: 10.1038/nchem.2439)
Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.
D Lücke, T Dalton, SV Ley, ZE Wilson
Chemistry (Weinheim an der Bergstrasse, Germany)
(2016)
22
(doi: 10.1002/chem.201504457)
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
J-S Poh, DL Browne, SV Ley
Reaction Chemistry & Engineering
(2016)
1
(doi: 10.1039/c5re00082c)
Controlled generation and use of CO in flow
SVF Hansen, ZE Wilson, T Ulven, SV Ley
Reaction Chemistry & Engineering
(2016)
1
(doi: 10.1039/c6re00020g)
Editorial-Flow Chemistry and Catalysis
SV Ley
Catalysis Science and Technology
(2016)
6
(doi: 10.1039/c6cy90064j)
Correction: Controlled generation and use of CO in flow
SVF Hansen, ZE Wilson, T Ulven, SV Ley
Reaction Chemistry & Engineering
(2016)
1
(doi: 10.1039/c6re90010k)
Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
N Holmes, GR Akien, RJD Savage, C Stanetty, IR Baxendale, AJ Blacker, BA Taylor, RL Woodward, RE Meadows, RA Bourne
Reaction Chemistry and Engineering
(2016)
1
(doi: 10.1039/c5re00083a)
Welcome to Reaction Chemistry & Engineering
SA Khan, IR Baxendale, JM Hawkins, SV Ley, K Jensen, V Hessel, G Luo, D Blackmond, A Katz, DG Vlachos, ME Davis
Reaction Chemistry & Engineering
(2016)
1
(doi: 10.1039/c6re90001a)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge