Yusuf Hamied Department of Chemistry

Publications by Professor Steve Ley CBE FRS FMedSci

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
BCS Cross, PJ Bond, PG Sadowski, BK Jha, J Zak, JM Goodman, RH Silverman, TA Neubert, IR Baxendale, D Ron, HP Harding
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1115623109)
Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin
Synthesis
(2012)
44
(doi: 10.1055/s-0031-1289676)
A-Ring Dihalogenation Increases the Cellular Activity of Combretastatin-Templated Tetrazoles
TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian
ACS medicinal chemistry letters
(2012)
3
(doi: 10.1021/ml200149g)
A Total Synthesis of Millingtonine A
J Wegner, SV Ley, A Kirschning, A-L Hansen, JM Garcia, IR Baxendale
Org Lett
(2012)
14
(doi: 10.1021/ol203158p)
Discovery, design and synthesis of a novel series of non-peptidomimetic inhibitors of XIAP-caspase 9 interactions
DM Allwood, RM Myers, F Richards, A Bender, C Watts, SV Ley
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243
Continuous stream processing: A prototype magnetic field induced flow mixer
P Koos, DL Browne, SV Ley
Green Processing and Synthesis
(2012)
1
(doi: 10.1515/greenps-2011-0501)
Twenty five years of azadirachtins
HE Hummel, DF Hein, W Kraus, SV Ley, ED Morgan, H Schmutterer
MITTEILUNGEN DER DEUTSCHEN GESELLSCHAFT FUR ALLGEMEINE UND ANGEWANDTE ENTOMOLOGIE, BD 18
(2012)
18
Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines
DL Browne, IR Baxendale, SV Ley
Tetrahedron
(2011)
67
(doi: 10.1016/j.tet.2011.09.146)
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.
KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley
Beilstein Journal of Organic Chemistry
(2011)
7
(doi: 10.3762/bjoc.7.194)
Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring
T Brodmann, P Koos, A Metzger, P Knochel, SV Ley
Organic Process Research & Development
(2011)
16
(doi: 10.1021/op200275d)
The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction
S Ley, S Bourne, P Koos, M O’Brien, B Martin, B Schenkel, I Baxendale
Synlett
(2011)
2011
(doi: 10.1055/s-0031-1289291)
Syngas-mediated C-C bond formation in flow: Selective rhodium-catalysed hydroformylation of styrenes
S Ley, S Kasinathan, S Bourne, P Tolstoy, P Koos, M O’Brien, R Bates, I Baxendale
Synlett
(2011)
2011
(doi: 10.1055/s-0031-1289292)
The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: using Teflon AF-2400 to effect gas/liquid contact.
TP Petersen, A Polyzos, M O'Brien, T Ulven, IR Baxendale, SV Ley
Chemsuschem
(2011)
5
(doi: 10.1002/cssc.201100339)
Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
P Koos, U Gross, A Polyzos, M O'Brien, I Baxendale, SV Ley
Org Biomol Chem
(2011)
9
(doi: 10.1039/c1ob06017a)
The flow synthesis of heterocycles for natural product and medicinal chemistry applications
M Baumann, IR Baxendale, SV Ley
Molecular Diversity
(2011)
15
(doi: 10.1007/s11030-010-9282-1)
Foreword
SV Ley
Practical Synthetic Organic Chemistry Reactions Principles and Techniques
(2011)
(doi: 10.1002/9781118093559)
Piperazic acid-containing natural products: isolation, biological relevance and total synthesis.
AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley
Natural product reports
(2011)
28
(doi: 10.1039/c1np00041a)
Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure
M O'Brien, N Taylor, A Polyzos, IR Baxendale, SV Ley
Chemical Science
(2011)
2
(doi: 10.1039/c1sc00055a)
A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.
DL Browne, M Baumann, BH Harji, IR Baxendale, SV Ley
Organic letters
(2011)
13
(doi: 10.1021/ol2010006)
The clerodane ring system: investigating the viability of a direct Diels-Alder approach
AT Merritt, RH Pouwer, DJ Williams, CM Williams, SV Ley
Org Biomol Chem
(2011)
9
(doi: 10.1039/c1ob05422h)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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