Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide.
I Paterson, K Ashton, R Britton, G Cecere, G Chouraqui, GJ Florence, J Stafford
– Angewandte Chemie International Edition
(2007)
46,
6167
(DOI: 10.1002/anie.200702178)
Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia
I Paterson, AD Findlay, GJ Florence
– Tetrahedron
(2007)
63,
5806
(DOI: 10.1016/j.tet.2007.01.048)
Synthesis and biological evaluation of novel analogues of dictyostatin
I Paterson, NM Gardner, KG Poullennec, AE Wright
– Bioorganic & Medicinal Chemistry Letters
(2007)
17,
2443
(DOI: 10.1016/j.bmcl.2007.02.031)
Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
I Paterson, NM Gardner
– Chemical communications (Cambridge, England)
(2007)
49
(DOI: 10.1039/b615122a)
Synthesis of two diastereomeric C<sub>1</sub>–C<sub>22</sub>fragments of spirastrellolide A
I Paterson, EA Anderson, SM Dalby, J Genovino, JH Lim, C Moessner
– Chemical Communications
(2007)
1852
(DOI: 10.1039/b700827a)
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
VM Sánchez-Pedregal, K Kubicek, J Meiler, I Lyothier, I Paterson, T Carlomagno
– Angewandte Chemie International Edition
(2006)
45,
7388
(DOI: 10.1002/anie.200602793)
Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.
I Paterson, EA Anderson, SM Dalby, JH Lim, P Maltas, C Moessner
– Chem Commun (Camb)
(2006)
4186
(DOI: 10.1039/b612697a)
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
E Hamel, BW Day, JH Miller, MK Jung, PT Northcote, AK Ghosh, DP Curran, M Cushman, KC Nicolaou, I Paterson, EJ Sorensen
– Molecular pharmacology
(2006)
70,
1555
(DOI: 10.1124/mol.106.027847)
Preparation of tritium‐labelled meta‐aminolevamisole of high specific radioactivity by catalytic dehalogenation
JA LEWIS, I PATERSON
– Journal of Labelled Compounds and Radiopharmaceuticals
(2006)
21,
945
(DOI: 10.1002/jlcr.2580211009)
Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19
I Paterson, AD Findlay, GJ Florence
– Organic letters
(2006)
8,
2131
(DOI: 10.1021/ol060609q)
Synthesis of novel 11-desmethyl analogues of laulimalide by Nozaki-Kishi coupling (vol 15, pg 2243, 2005)
I Paterson, H Bergmann, D Menche, A Berkessel
– Organic Letters
(2006)
8,
1511
(DOI: 10.1021/ol060252q)
Synthesis of the C1-C21 southern hemisphere of the originally proposed structure of spirastrellolide a
I Paterson, EA Anderson, SM Dalby
– Synthesis
(2005)
3225
(DOI: 10.1055/S-2005-918449)
Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity
RM Buey, I Barasoain, E Jackson, A Meyer, P Giannakakou, I Paterson, S Mooberry, JM Andreu, JF Díaz
– Chem Biol
(2005)
12,
1269
Advances in the Total Synthesis of Biologically Important Marine Macrolides †
K-S Yeung, I Paterson
– Chem Rev
(2005)
105,
4237
(DOI: 10.1021/cr040614c)
The Renaissance of Natural Products as Drug Candidates
I Paterson, EA Anderson
– Science
(2005)
310,
451
(DOI: 10.1126/science.1116364)
Toward the Synthesis of Spirastrellolide A: Construction of a Tetracyclic C<sub>26</sub>−C<sub>40</sub> Subunit Containing the DEF-Bis-Spiroacetal
I Paterson, EA Anderson, SM Dalby, O Loiseleur
– Org Lett
(2005)
7,
4121
(DOI: 10.1021/ol051403c)
Toward the Synthesis of Spirastrellolide A: Construction of Two C<sub>1</sub>−C<sub>25</sub> Diastereomers Containing the BC−Spiroacetal
I Paterson, EA Anderson, SM Dalby, O Loiseleur
– Organic Letters
(2005)
7,
4125
(DOI: 10.1021/ol051405x)
Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.
I Paterson, D Gottschling, D Menche
– Chemical communications (Cambridge, England)
(2005)
3568
(DOI: 10.1039/b505746a)
Development of a third-generation total synthesis of (+)-discodermolide: An expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate
I Paterson, I Lyothier
– JOURNAL OF ORGANIC CHEMISTRY
(2005)
70,
5494
(DOI: 10.1021/jo0505481a)
The stereocontrolled total synthesis of altohyrtin A /spongistatin 1: the southern hemisphere EF segment
I Paterson, MJ Coster, DY-K Chen, JL Aceña, J Bach, LE Keown, T Trieselmann
– Organic & Biomolecular Chemistry
(2005)
3,
2420
(DOI: 10.1039/b504149j)