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Yusuf Hamied Department of Chemistry

 
Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide.
I Paterson, K Ashton, R Britton, G Cecere, G Chouraqui, GJ Florence, J Stafford
– Angewandte Chemie International Edition
(2007)
46,
6167
Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia
I Paterson, AD Findlay, GJ Florence
– Tetrahedron
(2007)
63,
5806
Synthesis and biological evaluation of novel analogues of dictyostatin
I Paterson, NM Gardner, KG Poullennec, AE Wright
– Bioorganic & Medicinal Chemistry Letters
(2007)
17,
2443
Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
I Paterson, NM Gardner
– Chemical communications (Cambridge, England)
(2007)
49
Synthesis of two diastereomeric C<sub>1</sub>–C<sub>22</sub>fragments of spirastrellolide A
I Paterson, EA Anderson, SM Dalby, J Genovino, JH Lim, C Moessner
– Chemical Communications
(2007)
1852
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
VM Sánchez-Pedregal, K Kubicek, J Meiler, I Lyothier, I Paterson, T Carlomagno
– Angewandte Chemie International Edition
(2006)
45,
7388
Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.
I Paterson, EA Anderson, SM Dalby, JH Lim, P Maltas, C Moessner
– Chem Commun (Camb)
(2006)
4186
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
E Hamel, BW Day, JH Miller, MK Jung, PT Northcote, AK Ghosh, DP Curran, M Cushman, KC Nicolaou, I Paterson, EJ Sorensen
– Molecular pharmacology
(2006)
70,
1555
Preparation of tritium‐labelled meta‐aminolevamisole of high specific radioactivity by catalytic dehalogenation
JA LEWIS, I PATERSON
– Journal of Labelled Compounds and Radiopharmaceuticals
(2006)
21,
945
Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19
I Paterson, AD Findlay, GJ Florence
– Organic letters
(2006)
8,
2131
Synthesis of novel 11-desmethyl analogues of laulimalide by Nozaki-Kishi coupling (vol 15, pg 2243, 2005)
I Paterson, H Bergmann, D Menche, A Berkessel
– Organic Letters
(2006)
8,
1511
Synthesis of the C1-C21 southern hemisphere of the originally proposed structure of spirastrellolide a
I Paterson, EA Anderson, SM Dalby
– Synthesis
(2005)
3225
Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity
RM Buey, I Barasoain, E Jackson, A Meyer, P Giannakakou, I Paterson, S Mooberry, JM Andreu, JF Díaz
– Chem Biol
(2005)
12,
1269
Advances in the Total Synthesis of Biologically Important Marine Macrolides †
K-S Yeung, I Paterson
– Chem Rev
(2005)
105,
4237
The Renaissance of Natural Products as Drug Candidates
I Paterson, EA Anderson
– Science
(2005)
310,
451
Toward the Synthesis of Spirastrellolide A:  Construction of a Tetracyclic C<sub>26</sub>−C<sub>40</sub> Subunit Containing the DEF-Bis-Spiroacetal
I Paterson, EA Anderson, SM Dalby, O Loiseleur
– Org Lett
(2005)
7,
4121
Toward the Synthesis of Spirastrellolide A:  Construction of Two C<sub>1</sub>−C<sub>25</sub> Diastereomers Containing the BC−Spiroacetal
I Paterson, EA Anderson, SM Dalby, O Loiseleur
– Organic Letters
(2005)
7,
4125
Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.
I Paterson, D Gottschling, D Menche
– Chemical communications (Cambridge, England)
(2005)
3568
Development of a third-generation total synthesis of (+)-discodermolide: An expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate
I Paterson, I Lyothier
– JOURNAL OF ORGANIC CHEMISTRY
(2005)
70,
5494
The stereocontrolled total synthesis of altohyrtin A /spongistatin 1: the southern hemisphere EF segment
I Paterson, MJ Coster, DY-K Chen, JL Aceña, J Bach, LE Keown, T Trieselmann
– Organic &amp; Biomolecular Chemistry
(2005)
3,
2420