Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove.
NYS Lam, TP Stockdale, MJ Anketell, I Paterson
Chem Commun (Camb)
(2021)
57
The Stereocontrolled Total Synthesis of Polyketide Natural Products: A Thirty-Year Journey
TP Stockdale, NYS Lam, MJ Anketell, I Paterson
Bulletin of the Chemical Society of Japan
(2020)
94
Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification.
MJ Anketell, TM Sharrock, I Paterson
Organic and Biomolecular Chemistry
(2020)
18
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A
IE Ndukwe, X Wang, NYS Lam, K Ermanis, KL Alexander, MJ Bertin, GE Martin, G Muir, I Paterson, R Britton, JM Goodman, EJN Helfrich, J Piel, WH Gerwick, RT Williamson
Chemical communications (Cambridge, England)
(2020)
56
Stereocontrolled synthesis as an enabling tool for the configurational assignment of marine polyketide natural products
NYS Lam, I Paterson
European Journal of Organic Chemistry
(2020)
2020
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
Chemical communications (Cambridge, England)
(2020)
56
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti‐Trypanosomal Macrolides
MJ Anketell, TM Sharrock, I Paterson
Angewandte Chemie
(2020)
132
Towards the Total Synthesis of Hemicalide: Synthesis of the C27-C46 Region
TP Stockdale, BY Han, NYS Lam, JM Goodman, I Paterson
MARINE DRUGS
(2020)
18
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides.
MJ Anketell, TM Sharrock, I Paterson
Angewandte Chemie International Edition
(2019)
59
A counterintuitive stereochemical outcome from a chelation-controlled vinymetal aldehyde addition leads to the configurational reassignment of phormidolide A
NYS Lam, G Muir, VR Challa, R Britton, I Paterson
Chemical Communications
(2019)
55
Synthesis-enabled stereochemical assignment of the C1-C28 region of hemicalide: A potent cytotoxic polyketide of marine sponge origin
N Lam, BY Han, C MacGregor, J Goodman, I Paterson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Designed analogues of the aplyronines for next-generation antibody-drug conjugates
R Porter, T Pettigrew, I Paterson, D Spring, J Parker
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Toward the total synthesis of patellazole B: Synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton
AW Phillips, MJ Anketell, T Balan, NYS Lam, S Williams, I Paterson
Org Biomol Chem
(2018)
16
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine-site of tubulin
G Menchon, AE Prota, D Lucena-Agell, P Bucher, R Jansen, H Irschik, R Müller, I Paterson, JF Díaz, K-H Altmann, MO Steinmetz
Nature Communications
(2018)
9
A synthesis-enabled relative stereochemical assignment of the c1-C28 region of hemicalide
BY Han, NYS Lam, CI MacGregor, JM Goodman, I Paterson
Chemical Communications
(2018)
54
Toward aplyronine payloads for antibody-drug conjugates: total synthesis of aplyronines A and D.
N AnŽiček, S Williams, MP Housden, I Paterson
Organic and Biomolecular Chemistry
(2018)
16
Challenges and discoveries in the total synthesis of complex polyketide natural products
I Paterson, NYS Lam
J Antibiot (Tokyo)
(2017)
71
Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.
A Chan, C Gilfillan, N Templeton, I Paterson, PT Northcote, JH Miller
Investigational New Drugs
(2017)
35
Structural Basis of Microtubule Stabilization by Discodermolide
AE Prota, K Bargsten, M Redondo-Horcajo, AB Smith, C-PH Yang, HM McDaid, I Paterson, SB Horwitz, J Fernando Díaz, MO Steinmetz
Chembiochem
(2017)
18
Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration
JJ Field, PT Northcote, I Paterson, K-H Altmann, JF Díaz, JH Miller
International Journal of Molecular Sciences
(2017)
18