skip to content

Yusuf Hamied Department of Chemistry

 

Professor of Physical Chemistry and Biophysics

1920 Professor of Physical Chemistry

Our research

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Watch Professor Knowles discuss his research

Take a tour of the Sir Rodney Sweetnam laboratory

Publications

Clathrin-Inspired Coating and Stabilization of Liposomes by DNA Self-Assembly
KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S HERNANDEZ AINSA
(2019)
Rapid two-dimensional characterisation of proteins in solution.
KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
– Microsystems and Nanoengineering
(2019)
5,
33
Universality of filamentous aggregation phenomena.
TCT Michaels, AJ Dear, TPJ Knowles
– Physical review. E
(2019)
99,
062415
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.
S Zilberzwige-Tal, A Levin, Z Toprakcioglu, TPJ Knowles, E Gazit, J Elbaz
– Small (Weinheim an der Bergstrasse, Germany)
(2019)
15,
e1901780
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie International Edition
(2019)
58,
6640
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
– Science Advances
(2019)
5,
eaau3112
Sequence-Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons
C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll
– Advanced Functional Materials
(2019)
29,
1809112
3D Microfluidics Spray Nozzle for Sample Processing and Materials Deposition
T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet
– AIP Conference Proceedings
(2019)
2096,
020007
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
– Angewandte Chemie
(2019)
131,
6712
  • <
  • 37 of 70
  • >

Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk