skip to content

Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones
S Kumarn, DM Shaw, SV Ley
– Chemical Communications
(2006)
3211
Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools
SV Ley, IR Baxendale, DA Longbottom, RM Myers
(2006)
2,
51
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations
IR Baxendale, CM Griffiths-Jones, SV Ley, GK Tranmer
– Chemistry – A European Journal
(2006)
12,
4407
Microwave flow chemistry: The next evolutionary step in synthetic chemistry?
IR Baxendale, MR Pitts
– Chimica Oggi
(2006)
24,
41
Effect of azadirachtin‐derived decalin (perhydronaphthalene) and dihydrofuranacetal (furo[2, 3‐fo]pyran) fragments on the feeding behaviour of Spodoptera littoralis
WM BLANEY, MSJ SIMMONDS, SV LEY, JC ANDERSON, SC SMITH, A WOOD
– Pest Management Science
(2006)
40,
169
Progress towards avermectins and milbemycins
SV LEY
– Pesticide Science
(2006)
18,
153
Targeting C-reactive protein for the treatment of cardiovascular disease
MB Pepys, GM Hirschfield, GA Tennent, JR Gallimore, MC Kahan, V Bellotti, PN Hawkins, RM Myers, MD Smith, A Polara, AJA Cobb, SV Ley, JA Aquilina, CV Robinson, I Sharif, GA Gray, CA Sabin, MC Jenvey, SE Kolstoe, D Thompson, SP Wood
– Nature
(2006)
440,
1217
Chemical variation of natural product-like scaffolds: Design and synthesis of spiroketal derivatives
G Zinzalla, L-G Milroy, SV Ley
– Organic & Biomolecular Chemistry
(2006)
4,
1977
An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones
CET Mitchell, SE Brenner, J García-Fortanet, SV Ley
– Organic & biomolecular chemistry
(2006)
4,
2039
Quaternary Stereocenters
P Nolan
(2006)
xi
  • <
  • 45 of 108
  • >

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk