Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total synthesis of rapamycin
– Angewandte Chemie International Edition
(2007)
46,
591
(doi: 10.1002/anie.200604053)
Total synthesis of thapsigargin, a potent SERCA pump inhibitor.
– Organic letters
(2007)
9,
663
(doi: 10.1021/ol062947x)
Total Synthesis of Rapamycin
– Angewandte Chemie (International ed. in English)
(2007)
46,
591
(doi: 10.1002/anie.200604053)
Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development
(2007)
51
Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT
– CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96,
695
Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography
– CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96,
671
New avenues to efficient chemical synthesis
(2007)
151
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
– Chem Commun (Camb)
(2006)
4835
(doi: 10.1039/b612197g)
A new asymmetric organocatalytic nitrocyclopropanation reaction.
– Chemical Communications
(2006)
4838
(doi: 10.1039/b612436b)
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