Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Rearrangement reactions of bicyclic systems. Part IV. Acid-catalysed rearrangements of 5,6,7,8-tetrafluoro-1,4-dihydro-1-methoxy-3,9-dimethyl-1,4-ethenonaphthalene (1-methoxy-3,5-dimethyltetrafluorobenzobarrelene)
– J CHEM SOC PERK T 1
(1974)
2711
(doi: 10.1039/p19740002711)
Aryne chemistry. Part XXXIII. Reactions of tetrahalogenobenzynes with methoxyarenes and the photolysis and thermolysis of some of the products
– Journal of the Chemical Society, Perkin Transactions 1
(1974)
2681
(doi: 10.1039/p19740002681)
REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .2. REARRANGEMENTS OF 1-DIMETHYLAMINO-5,6,7,8-TETRAHALOGENO-1,4-DIHYDRO-1,4-ETHENONAPHTHALENE DERIVATIVES AND ANALOGOUS 5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-N-METHYL-1,4-IMINONAPHTHALENE IN AQUEOUS-SOLUTIONS
– J CHEM SOC PERK T 1
(1974)
2698
(doi: 10.1039/p19740002698)
Mećhanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts
– Tetrahedron Letters
(1973)
14,
2943
Rearrangement reactions of bicyclic systems. Part I. Synthesis of a model compound related to flavothebaone trimethyl ether. The abnormal ultraviolet absorption spectrum of flavothebaone and its trimethyl ether
– Journal of the Chemical Society Perkin Transactions 1
(1973)
1840
(doi: 10.1039/p19730001840)
N -alkylation of indole and pyrroles in dimethyl sulphoxide
– J CHEM SOC PERK T 1
(1973)
499
(doi: 10.1039/p19730000499)
Thermal reactions of 1,4-bridged-1,2,3,4-tetrahydronaphthalene derivatives
– Tetrahedron Letters
(1972)
13,
3067
ACID-CATALYSED REARRANGEMENTS OF 3,5-DIMETHYL-1-METHOXY-TETRAFLUORO-BENZOBARRELENE (5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-3,10-DIMETHYL-1-METHOXY-1,4-ETHENONAPHTHALENE)
– Journal of the Chemical Society D Chemical Communications
(1971)
1342
(doi: 10.1039/c29710001342)
Multiple rearrangement reactions of 1-methoxybenzobarrelene (1,4-dihydro-1-methoxy-1,4-ethenonaphthalene) derivatives
– Journal of the Chemical Society D: Chemical Communications
(1971)
224
(doi: 10.1039/c29710000224)
Rearrangement reactions of 1- NN -dimethylaminobenzobenzobarrelene derivatives (benzobarrelene = 1,4-dihydro-1,4-ethenonaphthalene)
– Journal of the Chemical Society D: Chemical Communications
(1970)
1184
(doi: 10.1039/C29700001184)
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