Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
ARYNE CHEMISTRY .35. REACTIONS OF ARYNES WITH 1-AMINOCYCLOALKENES AND HYDROLYSES OF ADDUCTS
– Journal of the Chemical Society, Perkin Transactions 1
(1974)
2693
(doi: 10.1039/p19740002693)
Aryne chemistry. Part XXXIV. Reactions of NN -dimethylarylamines with tetrahalogenobenzynes
– Journal of the Chemical Society, Perkin Transactions 1
(1974)
2688
(doi: 10.1039/p19740002688)
N-alkylation of indole and pyrroles in dimethyl sulphoxide
– J CHEM SOC PERK T 1
(1973)
499
(doi: 10.1039/P19730000499)
REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .1. SYNTHESIS OF A MODEL COMPOUND RELATED TO FLAVOTHEBAONE TRIMETHYL ETHER - ABNORMAL ULTRAVIOLET-ABSORPTION SPECTRUM OF FLAVOTHEBAONE AND ITS TRIMETHYL ETHER
– Journal of the Chemical Society Perkin Transactions 1
(1973)
1840
(doi: 10.1039/p19730001840)
Mećhanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts
– Tetrahedron Letters
(1973)
14,
2943
THERMAL REACTIONS OF 1,4-BRIDGED-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES
– Tetrahedron Letters
(1972)
13,
3067
Multiple rearrangement reactions of 1-methoxybenzobarrelene (1,4-dihydro-1-methoxy-1,4-ethenonaphthalene) derivatives
– Journal of the Chemical Society D Chemical Communications
(1971)
224
(doi: 10.1039/C29710000224)
Acid-catalysed rearrangements of 3,5-dimethyl-1-methoxy-tetrafluorobenzobarrelene (5,6,7,8-tetrafluoro-1,4-dihydro-3,10-dimethyl-1-methoxy-1,4-ethenonaphthalene)
– Journal of the Chemical Society D: Chemical Communications
(1971)
1342
(doi: 10.1039/c29710001342)
Rearrangement reactions of 1-NN-dimethylaminobenzobenzobarrelene derivatives (benzobarrelene = 1,4-dihydro-1,4-ethenonaphthalene)
– Journal of the Chemical Society D Chemical Communications
(1970)
1184
(doi: 10.1039/C29700001184)
A New Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
– Organic Letters
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