Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect
– Tetrahedron Letters
(1982)
23,
1207
Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction
– Journal of the Chemical Society, Chemical Communications
(1982)
1251
(doi: 10.1039/c39820001251)
AN UNEXPECTED REARRANGEMENT OF 4-ALKYLAMINOINDOLES
– Chemical Communications
(1982)
1356
(doi: 10.1039/c39820001356)
The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
– Journal of the Chemical Society, Perkin Transactions 1
(1982)
1005
(doi: 10.1039/p19820001005)
Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
2179
(doi: 10.1039/p19820002179)
SYNTHESIS OF METHYL-1,6-DIOXASPIRO[4,5]DECANES USING ORGANOSELENIUM MEDIATED CYCLIZATION REACTIONS
– Tetrahedron Letters
(1982)
23,
4625
A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
– Journal of the Chemical Society - Series Chemical Communications
(1982)
1252
(doi: 10.1039/c39820001252)
EXPERIMENTS ON THE SYNTHESIS OF TETRACYCLINE .16. IMPROVED PHOTOCYCLIC PREPARATION OF 12-KETO-DERIVATIVES AND THEIR DEPROTECTION USING BENZENESELENINIC ANHYDRIDE
– Journal of the Chemical Society, Perkin Transactions 1
(1981)
1840
(doi: 10.1039/P19810001840)
Synthesis of substituted cis-decalins as potential insect antifeedants
– Journal of the Chemical Society, Perkin Transactions 1
(1981)
1516
(doi: 10.1039/P19810001516)
Oxidation of phenols, pyrocatechols, and hydroquinones to ortho-quinones using benzeneseleninic anhydride
– Journal of the Chemical Society Perkin Transactions 1
(1981)
1473
(doi: 10.1039/P19810001473)
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