Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
TOTAL SYNTHESIS OF THE STRUCTURALLY UNIQUE IONOPHORE ANTIBIOTIC X-14547-A
– J. Chem. Soc., Chem. Commun.
(1983)
630
(doi: 10.1039/C39830000630)
Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes
– Journal of the Chemical Society, Perkin Transactions 1
(1983)
2851
(doi: 10.1039/p19830002851)
The Diels-Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1983)
1579
(doi: 10.1039/p19830001579)
Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids
– Tetrahedron Letters
(1983)
24,
5143
Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones
– Journal of the Chemical Society, Chemical Communications
(1983)
1281
(doi: 10.1039/c39830001281)
The total synthesis of the clerodane diterpene insect antifeedant ajugarin I
– Journal of the Chemical Society, Chemical Communications
(1983)
503
(doi: 10.1039/c39830000503)
A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
– Journal of the Chemical Society - Series Chemical Communications
(1982)
1252
(doi: 10.1039/c39820001252)
The X -ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
– Journal of the Chemical Society Perkin Transactions 1
(1982)
1005
(doi: 10.1039/p19820001005)
Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
– Journal of the Chemical Society, Perkin Transactions 1
(1982)
2179
(doi: 10.1039/p19820002179)
DEHYDROGENATION OF LACTONES USING BENZENESELENINIC ANHYDRIDE - X-RAY CRYSTAL-STRUCTURE OF 3-BETA-ACETOXY-14-ALPHA-HYDROXY-17A-OXA-D-HOMO-5-ALPHA-ANDROST-15-EN-17-ONE
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
1919
(doi: 10.1039/p19820001919)
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