Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
– J CHEM SOC PERK T 1
(1987)
121
(doi: 10.1039/p19870000121)
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
– Tetrahedron
(1987)
43,
2805
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
– Tetrahedron Letters
(1987)
28,
1595
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
– Journal of the Chemical Society, Perkin Transactions 1
(1987)
131
(doi: 10.1039/p19870000131)
Synthesis of a novel 3, 4-dihydromilbemycin analogue.
– Tetrahedron Letters
(1987)
28,
5759
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
– Tetrahedron Letters
(1987)
28,
3019
Application of ultrasound to the preparation of tricarbonyliron diene complexes
– Journal of Organometallic Chemistry
(1986)
302,
c13
(doi: 10.1016/0022-328x(86)80072-9)
X -Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
– Journal of the Chemical Society, Chemical Communications
(1986)
1,
46
(doi: 10.1039/c39860000046)
SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M-139603
– Tetrahedron Letters
(1986)
27,
105
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
– Tetrahedron
(1986)
42,
4333
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