Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
DIRECT SUBSTITUTION OF 2-BENZENESULFONYL CYCLIC ETHERS USING ORGANOZINC REAGENTS
– Tetrahedron Letters
(1988)
29,
4869
Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols
– Journal of the Chemical Society, Chemical Communications
(1987)
1625
(doi: 10.1039/C39870001625)
MICROBIAL OXIDATION IN SYNTHESIS - A 6 STEP PREPARATION OF (+/-)-PINITOL FROM BENZENE
– Tetrahedron Letters
(1987)
28,
225
A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques
– Tetrahedron Letters
(1987)
28,
5565
Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.
– Tetrahedron Letters
(1987)
28,
5755
DEVELOPMENT OF A SYNTHETIC ROUTE TOWARDS MILBEMYCIN-BETA-1 - PREPARATION OF AN ADVANCED MODEL SYSTEM
– Tetrahedron Letters
(1987)
28,
5763
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
– Tetrahedron Letters
(1987)
28,
221
PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES
– Tetrahedron Letters
(1987)
28,
345
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