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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
SV LEY, NJ ANTHONY, A ARMSTRONG, MG BRASCA, T CLARKE, D CULSHAW, C GRECK, P GRICE, AB JONES, B LYGO, A MADIN, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron
(1989)
45,
7161
(doi: 10.1016/S0040-4020(01)89182-1)
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL
– Tetrahedron Letters
(1989)
30,
3557
(doi: 10.1016/S0040-4039(00)99439-5)
Microbial oxidation in synthesis: Preparation from benzene of the cellular secondary messenger myo-inositol-1,4,5-trisphosphate (IP3) and related derivatives
SV LEY, F STERNFELD
– Tetrahedron Letters
(1988)
29,
5305
(doi: 10.1016/s0040-4039(00)80744-3)
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
CMJ FOX, SV LEY
– ORG SYNTH
(1988)
66,
108
(link to publication)
Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A
SV LEY, SC SMITH, PR WOODWARD
– Tetrahedron Letters
(1988)
29,
5829
(doi: 10.1016/S0040-4039(00)82204-2)
Chemistry of insect antifeedants from azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to 22,23-dihydro-23-β-methoxyazadirachtin.
SV LEY, JC ANDERSON, WM BLANEY, Z LIDERT, ED MORGAN, NG ROBINSON, MSJ SIMMONDS
– Tetrahedron Letters
(1988)
29,
5433
(doi: 10.1016/s0040-4039(00)82888-9)
PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULFONYL DERIVATIVES - A NEW MILD GLYCOSIDATION PROCEDURE
DS BROWN, SV LEY, S VILE
– Tetrahedron Letters
(1988)
29,
4873
(doi: 10.1016/S0040-4039(00)80631-0)
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
MG BRASCA, HB BROUGHTON, D CRAIG, SV LEY, AA SOMOVILLA, PL TOOGOOD
– Tetrahedron Letters
(1988)
29,
1853
(doi: 10.1016/s0040-4039(00)82062-6)
Chemistry of insect antifeedants from azadirachta indica (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons
JN BILTON, PS JONES, SV LEY, NG ROBINSON, RN SHEPPARD
– Tetrahedron Letters
(1988)
29,
1849
(doi: 10.1016/S0040-4039(00)82061-4)
Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (-)- and (+)-polygodial
Y Asakawa, GW Dawson, DC Griffiths, JY Lallemand, SV Ley, K Mori, A Mudd, M Pezechk-Leclaire, JA Pickett, H Watanabe, CM Woodcock, Z Zhong-Ning
– Journal of Chemical Ecology
(1988)
14,
1845
(doi: 10.1007/BF01013481)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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