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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Preparation of β-ketomacrolactones and β-ketodiolides using S-t-butyl 3-oxobutanethioate and S-t-butyl 4-diethylphosphono-3-oxobutanethioate
PM BOOTH, HB BROUGHTON, MJ FORD, CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS, PR WOODWARD
– Tetrahedron
(1989)
45,
7565
(doi: 10.1016/s0040-4020(01)89218-8)
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
NJ ANTHONY, A ARMSTRONG, SV LEY, A MADIN
– Tetrahedron Letters
(1989)
30,
3209
(doi: 10.1016/S0040-4039(00)99203-7)
The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal-metal pair interactions
IA KAHWA, S FOLKES, DJ WILLIAMS, SV LEY, CA OMAHONEY, GL MCPHERSON
– Journal of the Chemical Society, Chemical Communications
(1989)
1531
(doi: 10.1039/C39890001531)
THE STRUCTURE OF 2 NEW CLERODANE DITERPENOID POTENT INSECT ANTIFEEDANTS FROM SCUTELLARIA-WORONOWII (JUZ) - JODRELLIN-A AND JODRELLIN-B
JC ANDERSON, WM BLANEY, MD COLE, LL FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS
– Tetrahedron Letters
(1989)
30,
4737
(doi: 10.1016/S0040-4039(01)80789-9)
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINUM TRICHLORIDE
DS BROWN, SV LEY, M BRUNO
– Heterocycles
(1989)
28,
773
(doi: 10.3987/com-88-s145)
A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
SV LEY, NJ ANTHONY, A ARMSTRONG, MG BRASCA, T CLARKE, D CULSHAW, C GRECK, P GRICE, AB JONES, B LYGO, A MADIN, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron
(1989)
45,
7161
(doi: 10.1016/S0040-4020(01)89182-1)
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
SV LEY, F STERNFELD
– Tetrahedron
(1989)
45,
3463
(doi: 10.1016/s0040-4020(01)81025-5)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
SV LEY, JC ANDERSON, WM BLANEY, PS JONES, Z LIDERT, ED MORGAN, NG ROBINSON, D SANTAFIANOS, MSJ SIMMONDS, PL TOOGOOD
– Tetrahedron
(1989)
45,
5175
(doi: 10.1016/S0040-4020(01)81095-4)
The antifeedant activity of clerodane diterpenoids from Teucrium
MSJ SIMMONDS, WM BLANEY, SV LEY, G SAVONA, M BRUNO, B RODRIGUEZ
– Phytochemistry
(1989)
28,
1069
(doi: 10.1016/0031-9422(89)80184-0)
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF 6-DEOXY CYCLITOL ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE FROM BENZENE
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL
– Tetrahedron Letters
(1989)
30,
3557
(doi: 10.1016/s0040-4039(00)99439-5)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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    About the University

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