Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES

RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS

– Tetrahedron

(1990)

46,

4063

(doi: 10.1016/S0040-4020(01)90541-1)

Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.

JC ANDERSON, SV LEY

– Tetrahedron Letters

(1990)

31,

431

(doi: 10.1016/s0040-4039(00)94574-x)

TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols

WP Griffith, SV Ley

– Aldrichimica Acta

(1990)

23,

INSECT ANTIFEEDANTS

SV LEY, PL TOOGOOD

– CHEMISTRY IN BRITAIN

(1990)

26,

(link to publication)

Enantioselective synthesis of the C₃-C₁₁ hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).

SV LEY, GN MAW, ML TRUDELL

– Tetrahedron Letters

(1990)

31,

5521

(doi: 10.1016/s0040-4039(00)97888-2)

Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

SE DELASZLO, MJ FORD, SV LEY, GN MAW

– Tetrahedron Letters

(1990)

31,

5525

(doi: 10.1016/s0040-4039(00)97889-4)

DIRECT SUBSTITUTION OF 2-BENZENESULFONYLPIPERIDINES AND 2-BENZENESULFONYLPYRROLIDINES BY CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOID RUSPOLINONE

DS BROWN, T HANSSON, SV LEY

– Synlett

(1990)

1990,

(doi: 10.1055/s-1990-20983)

Neo-clerodane insect antifeedants from Scutellaria galericulata

MD COLE, JC ANDERSON, WM BLANEY, LE FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS

– Phytochemistry

(1990)

29,

1793

(doi: 10.1016/0031-9422(90)85018-B)

Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.

JC ANDERSON, SV LEY

– Tetrahedron Letters

(1990)

31,

3437

(doi: 10.1016/S0040-4039(00)97416-1)

Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles

DS BROWN, M BRUNO, RJ DAVENPORT, SV LEY

– Tetrahedron

(1989)

45,

4293

(doi: 10.1016/S0040-4020(01)81323-5)

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