Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).

SV Ley, GN Maw, ML Trudell

Tetrahedron Letters

(1990)

5521

(doi: 10.1016/S0040-4039(00)97888-2)

Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

SE de Laszlo, MJ Ford, SV Ley, GN Maw

Tetrahedron Letters

(1990)

5525

(doi: 10.1016/S0040-4039(00)97889-4)

TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols

WP Griffith, SV Ley

Aldrichimica Acta

(1990)

INSECT ANTIFEEDANTS

SV LEY, PL TOOGOOD

CHEM BRIT

(1990)

SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS

SV LEY

CIBA FOUNDATION SYMPOSIA

(1990)

154

PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES

SV Ley, DJ Wadsworth

Tetrahedron Letters

(1989)

1001

(doi: 10.1016/S0040-4039(00)95301-2)

PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE

PM Booth, HB Broughton, MJ Ford, CMJ Fox, SV Ley, AMZ Slawin, DJ Williams, PR Woodward

Tetrahedron

(1989)

7565

(doi: 10.1016/s0040-4020(01)89218-8)