Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Chemistry of insect antifeedants from Azadirachta indica (part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans -fused hydrobenzofuran fragments for azadirachtin synthesis
– J. Chem. Soc., Perkin Trans. 1
(1992)
2763
(doi: 10.1039/P19920002763)
ENABLING METHODOLOGY - THE SYNTHETIC CHEMISTS CONTRIBUTION TO MOLECULAR RECOGNITION
– MOLECULAR RECOGNITION : CHEMICAL AND BIOCHEMICAL PROBLEMS II
(1992)
111,
183
The use of π-allyltricarbonyliron lactone complexes in the synthesis of the β-lactone esterase inhibitor (−)-valilactone.
– Tetrahedron
(1991)
47,
9929
Synthesis of the alkaloids (−)-heliotridane and (−)-isoretronecanol via π-allyltricarbonyliron lactam complexes.
– Tetrahedron Letters
(1991)
32,
7119
(doi: 10.1016/0040-4039(91)85056-b)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .2. CHARACTERIZATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME NOVEL REARRANGED AZADIRACHTINS
– Tetrahedron
(1991)
47,
9231
Chemistry of insect antifeedants from azadirachta indica (Part 9): oxidative reactions of azadirachtin derivatives leading to C8-C14 bond cleavage.
– Tetrahedron Letters
(1991)
32,
6183
(doi: 10.1016/0040-4039(91)80784-4)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .10. SYNTHESIS OF A HIGHLY FUNCTIONALIZED DECALIN FRAGMENT OF AZADIRACHTIN
– Tetrahedron Letters
(1991)
32,
6187
(doi: 10.1016/0040-4039(91)80785-5)
The total synthesis of agglomerin A and (±)-carolinic acid. A general method for the preparation of 3-acyl tetronic acids via direct acylation of O-methyl 3-stannyl tetronates
– Tetrahedron
(1991)
47,
8285
Chemistry of insect antifeedants from azadirachta indica (part 8): Synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies.
– Tetrahedron
(1991)
47,
6813
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