Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total Synthesis of Avermectin B1a: Planning of the Synthesis and Preparation of the C1-C10 "Southern" Hydrobenzofuran Fragment
Synlett
(1990)
1990
323
(doi: 10.1055/s-1990-21078)
Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone
Synlett
(1990)
1990
331
(doi: 10.1055/s-1990-21081)
TOTAL SYNTHESIS OF AVERMECTIN B1A - FINAL COUPLING REACTIONS AND THE TOTAL SYNTHESIS OF AVERMECTIN B1A AGLYCONE
Synlett
(1990)
1990
328
(doi: 10.1055/s-1990-21080)
TOTAL SYNTHESIS OF AVERMECTIN B1A - SYNTHESIS OF THE C-11-C25 SPIROACETAL FRAGMENT
Synlett
(1990)
1990
326
(doi: 10.1055/s-1990-21079)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae.
Entomologia Experimentalis et Applicata.
(1990)
55
149
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae.
CrossRef Listing of Deleted DOIs
(1990)
55
169
A SIMPLE, ONE-POT, GLYCOSIDATION PROCEDURE VIA (1-IMIDAZOLYLCARBONYL) GLYCOSIDES AND ZINC BROMIDE
Synlett
(1990)
1990
255
(doi: 10.1055/s-1990-21053)
Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes
Synlett
(1990)
1990
224
(doi: 10.1055/s-1990-21044)
Direct substitution of 2-benzenesulphonylpiperidines and - Pyrrolidines by carbon nucleophiles: Synthesis of the pyrrolidine alkaloid ruspolinone
Synlett
(1990)
1990
48
(doi: 10.1055/s-1990-20983)
Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes
Tetrahedron
(1990)
46
4063
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