Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
FURTHER REACTIONS OF TERT-BUTYL 3-OXOBUTANTHIOATE AND TERT-BUTYL 4-DIETHYL-PHOSPHONO-3-OXOBUTANTHIOATE - CARBONYL COUPLING REACTIONS, AMINATION, USE IN THE PREPARATION OF 3-ACYLTETRAMIC ACIDS AND APPLICATION TO THE TOTAL SYNTHESIS OF FULIGORUBIN-A
Tetrahedron
(1992)
48
1145
Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)
Tetrahedron
(1992)
48
7899
Chemistry of insect antifeedants from azadirachta indica (Part 12): Use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1992)
2735
(doi: 10.1039/p19920002735)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .13. ON THE USE OF THE INTRAMOLECULAR DIELS-ALDER REACTION FOR THE CONSTRUCTION OF TRANS-FUSED HYDROBENZOFURAN FRAGMENTS FOR AZADIRACHTIN SYNTHESIS
Journal of the Chemical Society Perkin Transactions 1
(1992)
2763
(doi: 10.1039/p19920002763)
The use of π-allyltricarbonyliron lactone complexes in the synthesis of the β-lactone esterase inhibitor (−)-valilactone.
Tetrahedron
(1991)
47
9929
Synthesis of the alkaloids (-)-heliotridane and (-)-isoretronecanol via π-allyltricarbonyliron lactam complexes.
Tetrahedron Letters
(1991)
32
7119
(doi: 10.1016/0040-4039(91)85056-b)
Chemistry of insect antifeedants from Azadirachta indica (part 11): Characterisation and structure activity relationships of some novel rearranged azadirachtins.
Tetrahedron
(1991)
47
9231
Chemistry of insect antifeedants from azadirachta indica (Part 9): oxidative reactions of azadirachtin derivatives leading to C8-C14 bond cleavage.
Tetrahedron Letters
(1991)
32
6183
(doi: 10.1016/0040-4039(91)80784-4)
Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin.
Tetrahedron Letters
(1991)
32
6187
(doi: 10.1016/0040-4039(91)80785-5)
The total synthesis of agglomerin A and (±)-carolinic acid. A general method for the preparation of 3-acyl tetronic acids via direct acylation of O-methyl 3-stannyl tetronates
Tetrahedron
(1991)
47
8285
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