Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Alfred bader [2]
Chemical and Engineering News
(1992)
70
2
DISPIROKETALS IN SYNTHESIS .2. A NEW GROUP FOR THE SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES
Tetrahedron Letters
(1992)
33
4767
BADER,ALFRED
CHEMICAL & ENGINEERING NEWS
(1992)
70
2
Oxidation of activated halides to aldehydes and ketones by n-methylmorpholine-n-oxide
Synthetic Communications
(1992)
22
1967
(doi: 10.1080/00397919208021328)
TOTAL SYNTHESIS OF THE CARBOXYLIC-ACID IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN)
Synlett
(1992)
1992
395
(doi: 10.1055/s-1992-21357)
Total Synthesis of the Carboxylic Acid lonophore Antibiotic CP-61,405 (Routiennocin): Preparation of the Inherent Spiroketal Unit via a Reverse Coupling Process
Synlett
(1992)
1992
399
(doi: 10.1055/s-1992-21358)
Microbial Oxidation in Synthesis: Preparation of Pseudo-α-D-glucopyranose from Benzene
Synlett
(1992)
1992
291
(doi: 10.1055/s-1992-21342)
Dispiroketals in synthesis: Preparation of a stable, sterically demanding glyceraldehyde ketal and diastereoselective reactions with simple organometallic reagents
Synthesis
(1992)
1992
52
(doi: 10.1055/s-1992-34153)
ENABLING METHODOLOGY - THE SYNTHETIC CHEMISTS CONTRIBUTION TO MOLECULAR RECOGNITION
MOLECULAR RECOGNITION : CHEMICAL AND BIOCHEMICAL PROBLEMS II
(1992)
111
183
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