Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds
Synlett
(2002)
2002
0516
(doi: 10.1055/s-2002-20483)
Where are the women presidents? - Reply
CHEMISTRY IN BRITAIN
(2002)
38
20
A clean conversion of aldehydes to nitriles using a solid-supported hydrazine
Synlett
(2002)
2002
0775
(doi: 10.1055/s-2002-25333)
Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative
Angewandte Chemie International Edition
(2001)
40
4763
Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
J CHEM SOC PERK T 1
(2001)
2
143
(doi: 10.1039/b109482n)
Highly diastereoselective Michael addition reactions of butane-2,3-diacetal desymmetrized glycolic acid. Preparation of α-hydroxy-γ-amino acid derivatives
Organic letters
(2001)
3
3753
(doi: 10.1021/ol016708f)
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
Organic Letters
(2001)
3
3749
(doi: 10.1021/ol016707n)
Tetra-N-propylammonium perruthenate: A case study in catalyst recovery and re-use involving tetraalkylammonium salts
Chem Commun (Camb)
(2001)
1
2278
(doi: 10.1039/b107966m)
Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R ',R ',S,R)-2,3-butane diacetal protected butanetetraol derivatives
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2001)
1
2516
(doi: 10.1039/b105118k)
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