Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Toward a total synthesis of thapsigargin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U351
Development of an organic-catalyst mediated cyclopropanation reaction
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U361
Organic-catalyst-mediated cyclopropanation reaction.
Angew Chem Int Ed Engl
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones
Chemical communications (Cambridge, England)
(2003)
3
678
(doi: 10.1039/b300074p)
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
Synthesis of enantiomers of butane-1,2-diacetal-protected glyceraldehyde and of (R,R)-butane-1,2-diacetal-protected glycolic acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
Organic and Biomolecular Chemistry
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
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