Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Development of an indole safety-catch linker using analytical constructs.
Journal of Combinatorial Chemistry
(2004)
6
375
(doi: 10.1021/cc0499791)
Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactols
Organic & Biomolecular Chemistry
(2004)
2
1145
(doi: 10.1039/b316858a)
Catalytic polymer-supported potassium thiophenolate in methanol as a method for the removal of ester, amide, and thioacetate protecting groups
Synlett
(2004)
675
(doi: 10.1055/s-2004-817786)
5-Pyrrolidin-2-yltetrazole: A New, Catalytic, More Soluble Alternative to Proline in an Organocatalytic Asymmetric Mannich-type Reaction
Synlett
(2004)
2004
558
(doi: 10.1055/s-2004-817745)
Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors
Organic & Biomolecular Chemistry
(2004)
2
611
(doi: 10.1039/b313414h)
Preface - In honor of Professor Leo A. Paquette and on the occasion of his 70th birthday
HETEROCYCLES
(2004)
62
1
The synthesis of (-)-gloeosporone, a potent fungal autoinhibitor of spore germination using a π-allyltricarbonyl-iron lactone complex and a new reductive decomplexation procedure for the installation of the embedded 1,7-diol component of the natural product
Heterocycles
(2004)
62
619
(doi: 10.3987/com-03-s(p)55)
Synthesis of the nonamannan residue of a glycoprotein with high mannose content
Angewandte Chemie International Edition
(2003)
35
197
(doi: 10.1002/anie.199601971)
A Facile One‐Pot Synthesis of a Trisaccharide Unit from the Common Polysaccharide Antigen of Group B Streptococci Using Cyclohexane‐1, 2‐diacetal (CDA) Protected Rhamnosides
Angewandte Chemie International Edition in English
(2003)
33
2292
(doi: 10.1002/anie.199422921)
Cyclohexane‐1,2‐diacetals (CDA): A New Protecting Group for Vicinal Diols in Carbohydrates
Angewandte Chemie International Edition in English
(2003)
33
2290
(doi: 10.1002/anie.199422901)
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