Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Chiral glycolate equivalents for the asymmetric synthesis of α-hydroxycarbonyl compounds
– Bulletin of the Chemical Society of Japan
(2007)
80,
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
– Org Biomol Chem
(2007)
5,
2758
(doi: 10.1039/b709043a)
Total synthesis of five thapsigargins:: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition
– Chemistry A European Journal
(2007)
13,
5688
(doi: 10.1002/chem.200700302)
Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2007)
13,
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical strategy and innovation: An academics perspective
– Chemmedchem
(2007)
2,
768
(doi: 10.1002/cmdc.200700008)
(S)- And (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
– CHIMIA International Journal for Chemistry
(2007)
61,
247
(doi: 10.2533/chimia.2007.247)
Solid supported reagents in multi-step flow synthesis.
– Ernst Schering Foundation symposium proceedings
(2007)
2006/3,
151
(doi: 10.1007/2789_2007_033)
Chromatography-free suzuki reactions using a Polymer-Assisted Solution-Phase (PASP) approach
– Synlett
(2007)
2007,
1251
(doi: 10.1055/s-2007-977457)
A microcapillary flow disc reactor for organic synthesis
– Organic Process Research and Development
(2007)
11,
399
(doi: 10.1021/op700015f)
[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.
– Organic & Biomolecular Chemistry
(2007)
5,
1559
(doi: 10.1039/b702995k)
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