Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

Angew Chem Int Ed Engl

(2007)

2493

(doi: 10.1002/anie.200604688)

Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

L Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

Angewandte Chemie

(2007)

119

2545

(doi: 10.1002/ange.200604688)

Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells.

SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'

Archives of Insect Biochemistry and Physiology

(2007)

200

(doi: 10.1002/arch.20171)

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.

CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow

J Comb Chem

(2007)

422

(doi: 10.1021/cc060152b)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

Angewandte Chemie International Edition

(2007)

591

(doi: 10.1002/anie.200604053)

Total Synthesis of Thapsigargin, a Potent SERCA Pump Inhibitor

M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley

Organic letters

(2007)

663

(doi: 10.1021/ol062947x)

Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT

JG Eichhorn, C Fink, R Krissak, HJ Ruediger, S Ley, R Arnold, M Khalil, H-U Kauczor, M Gorenflo, HE Ulmer

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

695

Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography

JG Eichhorn, FR Long, S Hill, S Ley, M Gorenflo, R Arnold, H-U Kauczor, HE Ulmer, J Cheatham

CLINICAL RESEARCH IN CARDIOLOGY

(2007)

671

New avenues to efficient chemical synthesis

IR Baxendale, SV Ley

(2007)

151

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development

IR Baxendale, RM Myers, DA Longbottom, SV Ley

(2007)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Group

Research Interest Groups

Telephone number

Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge