Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Chromatography-Free Suzuki Reactions Using a Polymer-Assisted Solution-Phase (PASP) Approach

S Ley, E Vickerstaffe, A-L Villard, M Ladlow

Synlett

(2007)

2007

1251

(doi: 10.1055/s-2007-977457)

A Microcapillary Flow Disc Reactor for Organic Synthesis

CH Hornung, MR Mackley, IR Baxendale, SV Ley

Organic Process Research and Development

(2007)

11

399

(doi: 10.1021/op700015f)

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

CD Smith, IR Baxendale, S Lanners, JJ Hayward, SC Smith, SV Ley

Organic & Biomolecular Chemistry

(2007)

5

1559

(doi: 10.1039/b702995k)

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.

CD Smith, IR Baxendale, GK Tranmer, M Baumann, SC Smith, RA Lewthwaite, SV Ley

Organic and Biomolecular Chemistry

(2007)

5

1562

(doi: 10.1039/b703033a)

A fascination with 1,2-diacetals.

SV Ley, A Polara

J Org Chem

(2007)

72

5943

(doi: 10.1021/jo0703451)

Continuous flow ligand-free heck reactions using monolithic Pd [0] nanoparticles

N Nikbin, M Ladlow, SV Ley

Organic Process Research & Development

(2007)

11

458

(doi: 10.1021/op7000436)

Natural product synthesis: A stimulus for discovery

SV Ley

ABSTR PAP AM CHEM S

(2007)

233

Influence of microwave irradiation on the reaction of MgO and Al2O3 slurries to form layered double hydroxide

SJ Mitchell, IR Baxendale, W Jones

ABSTR PAP AM CHEM S

(2007)

233

205

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.

SP Andrews, MM Tait, M Ball, SV Ley

Organic & biomolecular chemistry

(2007)

5

1427

(doi: 10.1039/b702481a)

Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

KR Knudsen, J Holden, SV Ley, M Ladlow

Advanced Synthesis & Catalysis

(2007)

349

535

(doi: 10.1002/adsc.200600558)