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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A base-catalysed one-pot three-component coupling reaction leading to nitrosubstituted pyrroles
IR Baxendale, CD Buckle, SV Ley, L Tamborini
– Synthesis
(2009)
2009,
1485
(doi: 10.1055/s-0028-1087991)
Integrated Microwave Assisted Synthesis and Solid-Supported Reagents
IR Baxendale, AL Lee, SV Ley
(2009)
133
(doi: 10.1002/9781444305548.ch6)
Total Synthesis of Rapamycin
SV Ley, MN Tackett, ML Maddess, JC Anderson, PE Brennan, MW Cappi, JP Heer, C Helgen, M Kori, C Kouklovsky, SP Marsden, J Norman, DP Osborn, MA Palomero, JBJ Pavey, C Pinel, LA Robinson, J Schnaubelt, JS Scott, CD Spilling, H Watanabe, KE Wesson, MC Willis
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2009)
15,
2874
(doi: 10.1002/chem.200801656)
Second-generation synthesis of azadirachtin: A concise preparation of the propargylic mesylate fragment
A Boyer, GE Veitch, E Beckmann, SV Ley
– Angewandte Chemie International Edition
(2009)
48,
1317
(doi: 10.1002/anie.200805395)
Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis.
AC Evans, DA Longbottom, M Matsuoka, JE Davies, R Turner, V Franckevicius, SV Ley
– Organic & biomolecular chemistry
(2009)
7,
747
(doi: 10.1039/b813494d)
Synthesis and chemistry of the insectantifeedant azadirachtin
SV LEY
– Pure and Applied Chemistry
(2009)
66,
2099
(doi: 10.1351/pac199466102099)
Propranol-therapy of subglottic haemangioma in an infant with fulminant respiratory distress
JG Eichhorn, W Springer, JP Schenk, H Becker, S Ley, M Eggert, HE Ulmer
– CLINICAL RESEARCH IN CARDIOLOGY
(2009)
98,
604
(link to publication)
Stereoselective synthesis of inositol phosphates
SV LEY
– Pure and Applied Chemistry
(2009)
62,
2031
(doi: 10.1351/pac199062102031)
Development of methods suitable for natural product synthesis: The azadirachtin story
SV Ley
– Pure and Applied Chemistry
(2009)
77,
1115
(doi: 10.1351/pac200577071115)
Recent developments in natural product synthesis
SV LEY
– Pure and Applied Chemistry
(2009)
61,
401
(doi: 10.1351/pac198961030401)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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