Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total Synthesis of Chloptosin
– Angewandte Chemie (International ed. in English)
(2010)
49,
6139
(doi: 10.1002/anie.201002880)
KMnO4-mediated oxidation as a continuous flow process
– Organic letters
(2010)
12,
3618
(doi: 10.1021/ol101345z)
A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation
– Advanced Synthesis & Catalysis
(2010)
352,
1736
(doi: 10.1002/adsc.201000139)
Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes
– Synlett
(2010)
2010,
1919
(doi: 10.1055/s-0030-1258486)
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
– Organic & Biomolecular Chemistry
(2010)
8,
1798
(doi: 10.1039/b925327k)
Multiple Microcapillary Reactor for Organic Synthesis
– Industrial & Engineering Chemistry Research
(2010)
49,
4576
(doi: 10.1021/ie901674h)
Novel palindromic ligands cementing the native quaternary structure of transthyretin
– AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17,
49
Targeting transthyretin - X-ray crystallography and rational drug design
– AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17,
102
Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas - Liquid contact
– Organic letters
(2010)
12,
1596
(doi: 10.1021/ol100322t)
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