Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7‑Evoked Glutamate Release

C Battilocchio, L Guetzoyan, C Cervetto, L Di Cesare Mannelli, D Frattaroli, IR Baxendale, G Maura, A Rossi, L Sautebin, M Biava, C Ghelardini, M Marcoli, SV Ley

– ACS medicinal chemistry letters

(2013)

4,

704

(doi: 10.1021/ml400079h)

The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

IR Baxendale, S Cheung, MO Kitching, SV Ley, JW Shearman

– Bioorganic and Medicinal Chemistry

(2013)

21,

4378

(doi: 10.1016/j.bmc.2013.04.075)

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

K Nakayama, DL Browne, IR Baxendale, SV Ley

– Synlett

(2013)

24,

1298

(doi: 10.1055/s-0033-1338455)

A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

C Battilocchio, BJ Deadman, N Nikbin, MO Kitching, IR Baxendale, SV Ley

– Chemistry

(2013)

19,

7917

(doi: 10.1002/chem.201300696)

A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia

C Battilocchio, JM Hawkins, SV Ley

– Organic letters

(2013)

15,

2278

(doi: 10.1021/ol400856g)

Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low‐Temperature Flow Processes

DL Browne, BH Harji, SV Ley

– Chemical Engineering and Technology

(2013)

36,

959

(doi: 10.1002/ceat.201200581)

Synthesis of spongistatin 2 employing a new route to the EF fragment

H Kraus, A Français, M O’Brien, J Frost, A Diéguez-Vázquez, A Polara, N Baricordi, R Horan, DS Hsu, T Tsunoda, SV Ley

– Chemical Science

(2013)

4,

1989

(doi: 10.1039/c3sc50304f)

The integration of flow reactors into synthetic organic chemistry

IR Baxendale

– Journal of Chemical Technology & Biotechnology

(2013)

88,

519

(doi: 10.1002/jctb.4012)

Synthesis of (-)-hennoxazole A: Integrating batch and flow chemistry methods

A Fernández, ZG Levine, M Baumann, S Sulzer-Mossé, C Sparr, S Schläger, A Metzger, IR Baxendale, SV Ley

– Synlett

(2013)

24,

514

(doi: 10.1055/s-0032-1318109)

Synthesis of (–)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

A Fernández, ZG Levine, M Baumann, S Sulzer-Mossé, C Sparr, S Schläger, A Metzger, IR Baxendale, SV Ley

– Synlett

(2013)

23,

514

(doi: 10.1055/s-0032-1318109)