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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Fully automated sequence-specific synthesis of α-peptides using flow chemistry
KR Knudsen, M Ladlow, Z Bandpey, SV Ley
– Journal of Flow Chemistry
(2014)
4,
18
(doi: 10.1556/jfc-d-13-00033)
Investigation of a Lithium–Halogen Exchange Flow Process for the Preparation of Boronates by Using a Cryo‐Flow Reactor
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne
– Chemistry – A European Journal
(2013)
20,
263
(doi: 10.1002/chem.201303736)
Metal-Free Coupling of Saturated Heterocyclic Sulfonylhydrazones with Boronic Acids
DM Allwood, DC Blakemore, AD Brown, SV Ley
– Journal of Organic Chemistry
(2013)
79,
328
(doi: 10.1021/jo402526z)
Fragment-based hit identification: Thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt
– Drug Discovery Today
(2013)
18,
1221
(doi: 10.1016/j.drudis.2013.07.011)
Abstract B96: Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Molecular Cancer Therapeutics
(2013)
12,
B96
(doi: 10.1158/1535-7163.TARG-13-B96)
An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles
M Baumann, IR Baxendale
– Beilstein J Org Chem
(2013)
9,
2265
(doi: 10.3762/bjoc.9.265)
Sustainable flow oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst
R Chorghade, C Battilocchio, JM Hawkins, SV Ley
– Organic letters
(2013)
15,
5698
(doi: 10.1021/ol4027107)
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Chemistry & Biology
(2013)
20,
1399
(doi: 10.1016/j.chembiol.2013.09.012)
Flow‐Based, Cerium Oxide Enhanced, Low‐Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
C Battilocchio, BN Bhawal, R Chorghade, BJ Deadman, JM Hawkins, SV Ley
– Israel Journal of Chemistry
(2013)
54,
371
(doi: 10.1002/ijch.201300049)
Flow‐Based, Cerium Oxide Enhanced, Low‐Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
C Battilocchio, BN Bhawal, R Chorghade, BJ Deadman, JM Hawkins, SV Ley
– Israel Journal of Chemistry
(2013)
54,
371
(doi: 10.1002/ijch.201300049)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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