Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion.
– Organic letters
(2014)
16,
3064
(doi: 10.1021/ol5011714)
Accelerating spirocyclic polyketide synthesis using flow chemistry
– Angewandte Chemie International Edition
(2014)
53,
4915
(doi: 10.1002/anie.201402056)
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
– Organic and Biomolecular Chemistry
(2014)
12,
3611
(doi: 10.1039/c4ob00662c)
Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry
– Angew Chem Int Ed Engl
(2014)
53,
4915
(doi: 10.1002/anie.201402056)
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.
– Beilstein Journal of Organic Chemistry
(2014)
10,
641
(doi: 10.3762/bjoc.10.56)
Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide
– Organic letters
(2014)
16,
1060
(doi: 10.1021/ol403591c)
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
– Chemistry A European Journal
(2014)
20,
263
(doi: 10.1002/chem.201303736)
Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium
– Chemical communications (Cambridge, England)
(2014)
50,
8908
(doi: 10.1039/c4cc03766a)
Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
247,
Fully automated sequence-specific synthesis of α-peptides using flow chemistry
– Journal of Flow Chemistry
(2014)
4,
18
(doi: 10.1556/JFC-D-13-00033)
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