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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor: Ethyl 1-Benzyl-trans-5-( trifluoromethyl) pyrrolidine-3-carboxylate
DM Allwood, DL Browne, SV Ley, HE Peterlin, N Languille, M Faul
– Organic Syntheses
(2014)
91,
162
(doi: 10.15277/orgsyn.091.0162)
Preparation of Unsymmetrical Ketones from Tosylhydrazones and Aromatic Aldehydes via Formyl C–H Bond Insertion
DM Allwood, DC Blakemore, SV Ley
– Org Lett
(2014)
16,
3064
(doi: 10.1021/ol5011714)
Accelerating spirocyclic polyketide synthesis using flow chemistry
S Newton, CF Carter, CM Pearson, L De C. Alves, H Lange, P Thansandote, SV Ley
– Angewandte Chemie International Edition
(2014)
53,
4915
(doi: 10.1002/anie.201402056)
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
J Hartwig, JB Metternich, N Nikbin, A Kirschning, SV Ley
– Organic & Biomolecular Chemistry
(2014)
12,
3611
(doi: 10.1039/c4ob00662c)
Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry
S Newton, CF Carter, CM Pearson, L de C Alves, H Lange, P Thansandote, SV Ley
– Angew Chem Int Ed Engl
(2014)
53,
4915
(doi: 10.1002/anie.201402056)
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
RJ Ingham, C Battilocchio, JM Hawkins, SV Ley
– Beilstein Journal of Organic Chemistry
(2014)
10,
641
(doi: 10.3762/bjoc.10.56)
Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide
C Battilocchio, JM Hawkins, SV Ley
– Organic Letters
(2014)
16,
1060
(doi: 10.1021/ol403591c)
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne
– Chemistry A European Journal
(2014)
20,
263
(doi: 10.1002/chem.201303736)
Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts
RS Chorghade, C Battilocchio, SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
247,
(link to publication)
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
L Guetzoyan, RJ Ingham, N Nikbin, J Rossignol, M Wolling, M Baumert, NA Burgess-Brown, CM Strain-Damerell, L Shrestha, PE Brennan, O Fedorov, S Knapp, SV Ley
– RSC Medicinal Chemistry
(2014)
5,
540
(doi: 10.1039/c4md00007b)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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