Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Modeling mesoscale reactors for the production of fine chemicals

PM Witt, S Somasi, I Khan, DW Blaylock, JA Newby, SV Ley

Chemical Engineering Journal

(2015)

278

353

(doi: 10.1016/j.cej.2014.12.030)

Dynamic flow synthesis of porous organic cages.

ME Briggs, AG Slater, N Lunt, S Jiang, MA Little, RL Greenaway, T Hasell, C Battilocchio, SV Ley, AI Cooper

Chemical communications (Cambridge, England)

(2015)

51

17390

(doi: 10.1039/c5cc07447a)

An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins

S Ley, A Brahma, B Musio, U Ismayilova, N Nikbin, S Kamptmann, P Siegert, G Jeromin, M Pohl

Synlett

(2015)

27

262

(doi: 10.1055/s-0035-1560644)

Sequence-based Process Modeling of Fluidized Bed Biomass Gasification

H Asadi-Saghandi, A Sheikhi, R Sotudeh-Gharebagh

ACS Sustainable Chemistry & Engineering

(2015)

3

1453

(doi: 10.1021/acssuschemeng.5b00397)

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

IR Baxendale

Chemical Engineering & Technology

(2015)

38

1713

(doi: 10.1002/ceat.201500255)

The Use of Gases in Flow Synthesis

CJ Mallia, IR Baxendale

Organic Process Research and Development

(2015)

20

327

(doi: 10.1021/acs.oprd.5b00222)

Foreword

SV Ley

(2015)

xiii

(doi: 10.1016/b978-0-12-417205-0.00040-7)

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation.

JR Frost, CM Pearson, TN Snaddon, RA Booth, RM Turner, J Gold, DM Shaw, MJ Gaunt, SV Ley

Chemistry A European Journal

(2015)

21

13261

(doi: 10.1002/chem.201501877)

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

M Baumann, IR Baxendale

Beilstein Journal of Organic Chemistry

(2015)

11

1194

(doi: 10.3762/bjoc.11.134)

Machine-Assisted Organic Synthesis

SV Ley, DE Fitzpatrick, RM Myers, C Battilocchio, RJ Ingham

Angewandte Chemie - International Edition

(2015)

54

10122

(doi: 10.1002/anie.201501618)