Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Sequence-based Process Modeling of Fluidized Bed Biomass Gasification
– ACS Sustainable Chemistry & Engineering
(2015)
3,
2640
A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component
– Chemical Engineering & Technology
(2015)
38,
1713
(doi: 10.1002/ceat.201500255)
The Use of Gases in Flow Synthesis
– Organic Process Research and Development
(2015)
20,
327
(doi: 10.1021/acs.oprd.5b00222)
Callipeltosides A, B and C: Total Syntheses and Structural Confirmation
– Chemistry A European Journal
(2015)
21,
13261
(doi: 10.1002/chem.201501877)
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.
– Beilstein journal of organic chemistry
(2015)
11,
1194
(doi: 10.3762/bjoc.11.134)
Machine-Assisted Organic Synthesis.
– Angewandte Chemie (International ed. in English)
(2015)
54,
10122
(doi: 10.1002/anie.201501618)
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors
– European Journal of Medicinal Chemistry
(2015)
101,
223
(doi: 10.1016/j.ejmech.2015.07.011)
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
– Synlett
(2015)
26,
1470
(doi: 10.1055/s-0034-1380679)
Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439
– Organic Letters
(2015)
17,
3218
(doi: 10.1021/acs.orglett.5b01307)
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