Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

SYNTHESIS OF (+/-)-CIS-6-METHYLTETRAHYDROPYRAN-2-YLACETIC ACID, A NATURAL PRODUCT FROM VIVERRA-CIVETTA, USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS

SV Ley, B Lygo, H Molines

Journal of the Chemical Society Perkin Transactions 1

(1984)

2403

(doi: 10.1039/P19840002403)

Fe2(co)g in tetrahydrofuran or under sonochemical conditions as convenient practical routes to π-allyltricarbonyliron lactone complexes

AM Horton, DM Hollinshead, SV Ley

Tetrahedron

(1984)

1737

(doi: 10.1016/S0040-4020(01)91124-X)

SYNTHESIS OF SPIROACETALS USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS - X-RAY MOLECULAR-STRUCTURE OF (2S,8R)-8-METHYL-2-PHENYL-1,7-DIOXASPIRO[5.5]UNDECAN-4(R)-OL

AM Doherty, SV Ley, B Lygo, DJ Williams

Journal of the Chemical Society Perkin Transactions 1

(1984)

1371

(doi: 10.1039/p19840001371)

STEREOCHEMISTRY OF A 5,5,10-TRIMETHYL-2-DECALONE BY PROTON NUCLEAR MAGNETIC-RESONANCE - A NEW APPLICATION OF INDOR DIFFERENCE SPECTROSCOPY

SV LEY, AJ WHITTLE, GE HAWKES

J CHEM RES-S

(1983)

210

Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes

GD Annis, EM Hebblethwaite, ST Hodgson, DM Hollinshead, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1983)

2851

(doi: 10.1039/p19830002851)

The total synthesis of the clerodane diterpene insect antifeedant ajugarin I

SV Ley, NS Simpkins, AJ Whittle

Journal of the Chemical Society Chemical Communications

(1983)

503

(doi: 10.1039/c39830000503)

Total synthesis of the structurally unique ionophore antibiotic X-14547 A

MP Edwards, SV Ley, SG Lister, BD Palmer

J. Chem. Soc., Chem. Commun.

(1983)

630

(doi: 10.1039/c39830000630)

The Diels–Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal

DM Hollinshead, SC Howell, SV Ley, M Mahon, NM Ratcliffe, PA Worthington

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1983)

1579

(doi: 10.1039/p19830001579)

Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones

SV Ley, NS Simpkins

Chemical Communications

(1983)

1281

(doi: 10.1039/c39830001281)

Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids

PM Booth, CMJ Fox, SV Ley

Tetrahedron Letters

(1983)

5143

(doi: 10.1016/S0040-4039(00)94065-6)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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