Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
Wittig and horner-wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis
Tetrahedron
(1985)
41
3825
Structural reappraisal of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1985)
968
(doi: 10.1039/c39850000968)
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
J. Chem. Soc., Chem. Commun.
(1985)
1805
(doi: 10.1039/c39850001805)
Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[( p -benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one
Journal of the Chemical Society Perkin Transactions 1
(1985)
2375
(doi: 10.1039/P19850002375)
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
J CHEM SOC PERK T 1
(1985)
1949
(doi: 10.1039/p19850001949)
FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES
Tetrahedron
(1984)
40
1737
A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS
Tetrahedron Letters
(1984)
25
113
Oxo complexes of ruthenium( VI ) and ( VII ) as organic oxidants
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1984)
681
(doi: 10.1039/p19840000681)
Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X -Ray molecular structure of (2 S ,8 R )-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4( R )-ol
Journal of the Chemical Society Perkin Transactions 1
(1984)
1371
(doi: 10.1039/p19840001371)
- ‹ previous
- Page 94
