Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
MICROBIAL OXIDATION IN SYNTHESIS - A 6 STEP PREPARATION OF (+/-)-PINITOL FROM BENZENE
Tetrahedron Letters
(1987)
28
225
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
221
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
1595
CORRECTION
TETRAHEDRON LETTERS
(1987)
28
1594
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
C13
(doi: 10.1016/0022-328x(86)80072-9)
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M-139603
Tetrahedron Letters
(1986)
27
105
PREPARATION OF SPIROKETALS BY REACTION OF ANIONS FROM 2-BENZENESULPHONYLTETRAHYDROPYRANS WITH EPOXIDES - SYNTHESIS OF THE C-11 TO C-25 FRAGMENT OF THE MILBEMYCINS
Tetrahedron Letters
(1986)
27
5277
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
Tetrahedron
(1986)
42
4333
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
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