Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols

WP Griffith, SV Ley, GP Whitcombe, AD White

Journal of the Chemical Society Chemical Communications

(1987)

1625

(doi: 10.1039/c39870001625)

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, AMZ Slawin, DJ Williams, Z Lidert, ED Morgan

Tetrahedron

(1987)

43

2805

(doi: 10.1016/s0040-4020(01)86886-1)

Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

PM Booth, CMJ Fox, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1987)

121

(doi: 10.1039/p19870000121)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T Clarke, SV Ley

J CHEM SOC PERK T 1

(1987)

131

(doi: 10.1039/p19870000131)

DEVELOPMENT OF A SYNTHETIC ROUTE TOWARDS MILBEMYCIN-BETA-1 - PREPARATION OF AN ADVANCED MODEL SYSTEM

NJ Anthony, P Grice, SV Ley

Tetrahedron Letters

(1987)

28

5763

(doi: 10.1016/S0040-4039(00)96835-7)

SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG

C Greck, P Grice, AB Jones, SV Ley

Tetrahedron Letters

(1987)

28

5759

(doi: 10.1016/s0040-4039(00)96834-5)

Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.

NJ Anthony, T Clarke, AB Jones, SV Ley

Tetrahedron Letters

(1987)

28

5755

(doi: 10.1016/s0040-4039(00)96833-3)

A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES

GH Baker, PJ Brown, RJJ Dorgan, JR Everett, SV Ley, AMZ Slawin, DJ Williams

Tetrahedron Letters

(1987)

28

5565

(doi: 10.1016/s0040-4039(00)96783-2)

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

3019

(doi: 10.1016/s0040-4039(00)96273-7)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

345

(doi: 10.1016/s0040-4039(00)95725-3)