Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles

DS Brown, M Bruno, RJ Davenport, SV Ley

Tetrahedron

(1989)

45

4293

(doi: 10.1016/s0040-4020(01)81323-5)

Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids

SV Ley, JC Anderson, WM Blaney, PS Jones, Z Lidert, ED Morgan, NG Robinson, D Santafianos, MSJ Simmonds, PL Toogood

Tetrahedron

(1989)

45

5175

(doi: 10.1016/S0040-4020(01)81095-4)

Microbial Oxidation in Synthesis: Preparation of (+)- and (−)-Pinitol from Benzene

SV Ley, F Sternfeld

Tetrahedron

(1989)

45

3463

(doi: 10.1016/S0040-4020(01)81025-5)

Substitution Reactions of 2-Benzensulphonyl Cyclic Ethers with Silyl Enol Ethers Promoted by Aluminium Trichloride

S V. Ley, D S. Brown, M Bruno

Heterocycles

(1989)

28

773

(doi: 10.3987/com-88-s145)

ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX

C TERHORST, B ALARCON, B BERKHOUT, R BLUMBERG, H CLEVERS, K GEORGOPOULOS, C HALL, S LEY, J SANCHO, J VERSTEEGEN, T WILEMAN

PROGRESS IN IMMUNOLOGY, VOL 7

(1989)

33

TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1

NJ Anthony, A Armstrong, SV Ley, A Madin

Tetrahedron Letters

(1989)

30

3209

(doi: 10.1016/S0040-4039(00)99203-7)

The antifeedant activity of clerodane diterpenoids from Teucrium

MSJ Simmonds, WM Blaney, SV Ley, G Savona, M Bruno, B Rodriguez

Phytochemistry

(1989)

28

1069

(doi: 10.1016/0031-9422(89)80184-0)

The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal-metal pair interactions

IA Kahwa, S Folkes, DJ Williams, SV Ley, CA O'Mahoney, GL McPherson

J. Chem. Soc., Chem. Commun.

(1989)

1531

(doi: 10.1039/c39890001531)

The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B

JC Anderson, WM Blaney, MD Cole, LL Fellows, SV Ley, RN Sheppard, MSJ Simmonds

Tetrahedron Letters

(1989)

30

4737

(doi: 10.1016/S0040-4039(01)80789-9)

Organic synthesis with tricarbonyliron lactone complexes

SV Ley

Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences

(1988)

326

633

(doi: 10.1098/rsta.1988.0114)