Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
Tetrahedron Letters
(1990)
31
3445
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .7. PREPARATION OF AN OPTICALLY PURE HYDROXYACETAL EPOXIDE RELATED TO AZADIRACHTIN
Tetrahedron Letters
(1990)
31
3437
DIRECT SUBSTITUTION OF 2-BENZENESULFONYLPIPERIDINES AND 2-BENZENESULFONYLPYRROLIDINES BY CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOID RUSPOLINONE
Synlett
(1990)
1990
48
(doi: 10.1055/s-1990-20983)
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II
(1990)
79
90
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .6. SYNTHESIS OF AN OPTICALLY PURE ACETAL INTERMEDIATE FOR POTENTIAL USE IN THE SYNTHESIS OF AZADIRACHTIN AND NOVEL ANTIFEEDANTS
Tetrahedron Letters
(1990)
31
431
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
Tetrahedron Letters
(1989)
30
3557
Preparation of β-ketomacrolactones and β-ketodiolides using S-t-butyl 3-oxobutanethioate and S-t-butyl 4-diethylphosphono-3-oxobutanethioate
Tetrahedron
(1989)
45
7565
PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES
Tetrahedron Letters
(1989)
30
1001
Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment
Tetrahedron
(1989)
45
2143
A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
Tetrahedron
(1989)
45
7161
- ‹ previous
- Page 88
