Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

1,5-Asymmetric induction of chirality: Diastereoselective addition of organoaluminium reagents and allylstannanes into aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes

SV Ley, S Burckhardt, LR Cox, G Meek

Journal of the Chemical Society, Perkin Transactions 1

(1997)

3327

(doi: 10.1039/a704487i)

Rapid access to rare natural pyranosides using 1,2-diacetal protected intermediates

SV Ley, DR Owen, KE Wesson

Journal of the Chemical Society, Perkin Transactions 1

(1997)

2805

(doi: 10.1039/a705360f)

Direct preparation of diacetals from 1,2-diketones and their use as 1,2-diol protecting groups

A Hense, SV Ley, HMI Osborn, DR Owen, J-F Poisson, SL Warriner, KE Wesson

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1997)

2023

(doi: 10.1039/a702497e)

Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis

B Hinzen, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1997)

1907

(doi: 10.1039/a703461j)

Molybdenum(II)-catalyzed allylic substitution

AV Malkov, I Baxendale, DJ Mansfield, P Kočovsky

Tetrahedron Letters

(1997)

4895

(doi: 10.1016/s0040-4039(97)01052-6)

Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex

SV Ley, G Meek

Journal of the Chemical Society Perkin Transactions 1

(1997)

1125

(doi: 10.1039/a607376j)

Synthesis and chemistry of dispiroacetals and other 1,2-diacetals.

SV Ley

ABSTR PAP AM CHEM S

(1997)

213

Dispiroketals in synthesis .23. A new route to (+)-D-conduritol B from myo-inositol

JE Innes, PJ Edwards, SV Ley

J CHEM SOC PERK T 1

(1997)

795

(doi: 10.1039/a700422b)

Preparation, structure, derivatisation and NMR data of cyclohexane-1,2-diacetal protected carbohydrates

P Grice, SV Ley, J Pietruszka, HWM Priepke, SL Warriner

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1997)

351

(doi: 10.1039/a605851e)

Autoradiographic localization of [22, 23-H-3(2)] dihydroazadirachtin binding sites in desert locust testes and effects of azadirachtin on sperm motility (vol 28, pg 725, 1996)

AJ Nisbet, AJ Mordue, LM Williams, L Hannah, L Jennens, SV Ley, W Mordue

TISSUE CELL

(1997)

129

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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