Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols
Tetrahedron: Asymmetry
(1998)
9
2471
Mukaiyama aldol reactions of π-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains.: Not just formal, but genuine 1,7 induction of chirality
Chemical Communications
(1998)
1339
(doi: 10.1039/a802878h)
A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents:: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols (pg 229, 1998)
CHEM COMMUN
(1998)
851
Highly diasteroselective synthesis of beta-hydroxy carbonyl compounds using pi-allyltricarbonyliron lactone complexes: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction (pg 227, 1998)
CHEMICAL COMMUNICATIONS
(1998)
851
Highly diastereoselective synthesis of beta-hydroxy carbonyl compounds using pi-allyltricarbonyliron lactone complexes: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction
Chemical Communications
(1998)
227
(doi: 10.1039/a707153a)
A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents:: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
Chemical Communications
(1998)
229
(doi: 10.1039/a707155h)
Tuning glycoside reactivity:: New tool for efficient oligosaccharide synthesis
J CHEM SOC PERK T 1
(1998)
51
(doi: 10.1039/a705275h)
Synthesis of isoxazolidines using polymer supported perruthenate (PSP)
Journal of the Chemical Society, Perkin Transactions 1
(1998)
1
(doi: 10.1039/a707340b)
(1′S,2′S)-methyl-3O,4O-(1′,2′-dimethoxycyclohexane-1′,2′-diyl)-α-D-mannopyranoside [α-D-Mannopyranoside, methyl 3,4-O-(1,2-dimethoxy- 1,2-cyclohexanediyl)-, [3[S (S)]]-]
Organic Syntheses
(1998)
75
170
(doi: 10.15227/orgsyn.075.0170)
Studies towards the synthesis of the C29-C51 fragment of altohyrtin A
Synlett
(1998)
1998
991
(doi: 10.1055/s-1998-3140)
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