Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Polymer-supported hypervalent iodine reagents in 'clean' organic synthesis with potential application in combinatorial chemistry

SV Ley, AW Thomas, H Finch

J CHEM SOC PERK T 1

(1999)

669

(doi: 10.1039/a809799b)

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine †

DJ Dixon, SV Ley, T Gracza, P Szolcsanyi

Journal of the Chemical Society, Perkin Transactions 1

(1999)

839

(doi: 10.1039/a809823i)

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1639

(doi: 10.1039/a900950g)

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

1647

(doi: 10.1039/a900951e)

Synthesis of the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1999)

1253

(doi: 10.1039/a901802f)

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols - synthesis and utility of (R ',R ',S,R)-2,3-butane diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1635

(doi: 10.1039/a902732g)

Assembly of dendritic glycoclusters from monomeric mannose building blocks

P Langer, SJ Ince, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1998)

3913

(doi: 10.1039/a807621i)

Total synthesis of the protein phosphatase inhibitor okadaic acid

SV Ley, AC Humphries, H Eick, R Downham, AR Ross, RJ Boyce, JBJ Pavey, J Pietruszka

Journal of the Chemical Society, Perkin Transactions 1

(1998)

3907

(doi: 10.1039/a807957i)

Characterization of azadirachtin binding to Sf9 nuclei in vitro

AJ Nisbet, AJ Mordue, RB Grossman, L Jennens, SV Ley, W Mordue

Archives of Insect Biochemistry and Physiology

(1998)

461

(doi: 10.1002/(sici)1520-6327(1997)34:4<461::aid-arch5>3.0.co;2-v)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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