Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
– Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
(2001)
40,
1043
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers (Sept, pg 1482, 2001)
– Synlett
(2001)
2004
A New Route to Butane-1,2-diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products
– Synlett
(2001)
2001,
1793
(doi: 10.1055/s-2001-18087)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
– Canadian Journal of Chemistry
(2001)
79,
1668
(doi: 10.1139/cjc-79-11-1668)
New polyethylene glycol polymers as ketal protecting groups - A polymer supported approach to symmetrically substituted spiroketals
– Synthetic Communications
(2001)
31,
2965
(doi: 10.1081/scc-100105668)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
– Canadian Journal of Chemistry
(2001)
79,
1668
(doi: 10.1139/cjc-79-11-1668)
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers
– Synlett
(2001)
2001,
1482
(doi: 10.1055/s-2001-16783)
Molybdenum( 0 ) and tungsten( 0 ) catalysts with enhanced reactivity for allylic substitution: regioselectivity and solvent effects
– Journal of the Chemical Society Perkin Transactions 1
(2001)
1234
(doi: 10.1039/b100903f)
Solid-phase reaction monitoring - Chemical derivatization and off-bead analysis
– Biotechnology and Bioengineering
(2001)
71,
110
1,2-diacetals: a new opportunity for organic synthesis.
– Chemical Reviews
(2000)
101,
53
(doi: 10.1021/cr990101j)
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