Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Rapid assembly of oligosaccharides: 1,2-Diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
Tetrahedron: Asymmetry
(2000)
11
173
A Short and Efficient Stereoselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin
Org Lett
(2000)
2
123
(doi: 10.1021/ol991214s)
Asymmetric molybdenum-catalyzed allylic substitution.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
Membership changes - Reply
CHEMISTRY IN BRITAIN
(2000)
36
23
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
Parallel solution-phase syntheses of functionalised bicyclo-[2.2.2]octanes: Generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants
Journal of the Chemical Society Perkin Transactions 1
(2000)
3645
(doi: 10.1039/b003129l)
Deracemization of Baylis-Hillman adducts
Chemtracts
(2000)
13
596
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