Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
– Journal of Organic Chemistry
(2002)
56,
5739
(doi: 10.1021/jo00020a002)
Nitrogen Analogs of 1,6-Methano[12]annulene. Effect on Valence Tautomerism of the Locus of Aza Substitution
– The Journal of Organic Chemistry
(2002)
40,
902
(doi: 10.1021/jo00895a020)
Alkali metal reduction studies of cis- and trans-bicyclo[6.1.0]nona-2,4,6-trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions
– Journal of the American Chemical Society
(2002)
96,
6670
(doi: 10.1021/ja00828a021)
Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
– The Journal of Physical Chemistry
(2002)
96,
7021
(doi: 10.1021/j100196a033)
Homotropylium-8-sulfinate complexes by antimony pentafluoride-promoted ring opening of 9-thiabicyclo[4.2.1]nona-2,4,7-triene and 9-thiabarbaralane 9,9-dioxides
– Journal of the American Chemical Society
(2002)
98,
152
(doi: 10.1021/ja00417a023)
Total synthesis of the ionophore antibiotic X-14547A (Indanomycin)
– The Journal of Organic Chemistry
(2002)
49,
3503
(doi: 10.1021/jo00193a014)
Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction
– Journal of the American Chemical Society
(2002)
96,
5806
(doi: 10.1021/ja00825a019)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions
– Journal of Organic Chemistry
(2002)
43,
4712
(doi: 10.1021/jo00419a007)
Encapsulation of palladium in polyurea microcapsules.
– Chemical Communications
(2002)
10,
1132
(doi: 10.1039/b200674j)
Polyurea-encapsulated palladium(II) acetate: A robust and recyclable catalyst for use in conventional and supercritical media
– Chemical Communications
(2002)
2,
1134
(doi: 10.1039/b200677b)
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