Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using pi-allyltricarbonyliron lactone complexes.
– Chemical Communications
(2002)
2,
1624
(doi: 10.1039/b204994p)
Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research for a Postdoctoral Fellowship (to I.R.B.), the BP endowment and the Novartis Research Fellowship (to S.V.L.), and Pharmacia & Upjohn (to C.P.).
– Angew Chem Int Ed Engl
(2002)
41,
2194
Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation
– Journal of the American Chemical Society
(2002)
98,
8162
(doi: 10.1021/ja00441a046)
Immobilization of Thallium by Tandem Oxidation/Reduction-Complexation of Thallium(I/III)
– Inorganic Chemistry
(2002)
31,
3963
(doi: 10.1021/ic00045a020)
LUMINESCENCE DYNAMICS AND C-13 NMR CHARACTERISTICS OF DINUCLEAR COMPLEXES EXHIBITING COUPLED LANTHANIDE(III) CATION PAIRS
– The Journal of Physical Chemistry
(2002)
96,
7021
(doi: 10.1021/j100196a033)
HOMOTROPYLIUM-8-SULFINATE COMPLEXES BY SBF5-PROMOTED RING-OPENING OF 9-THIABICYCLO[4.2.1]NONA-2,4,7-TRIENE AND 9-THIABARBARALANE 9,9-DIOXIDES
– Journal of the American Chemical Society
(2002)
98,
152
(doi: 10.1021/ja00417a023)
Nitrogen Analogs of 1,6-Methano[12]annulene. Effect on Valence Tautomerism of the Locus of Aza Substitution
– The Journal of Organic Chemistry
(2002)
40,
902
(doi: 10.1021/jo00895a020)
A FACILE ROUTE TO IMIDAZOL-4-YL ANIONS AND THEIR REACTION WITH CARBONYL-COMPOUNDS
– Journal of Organic Chemistry
(2002)
56,
5739
(doi: 10.1021/jo00020a002)
QUESTION OF DELOCALIZATION IN ANCHORED IONS WITH POTENTIAL TRIS-HOMO-AROMATIC CHARACTER .1. REDUCTION OF TRICYCLO[5.4.1.O4,12]DODECA-2,5,8,10-TETRAENE AS A ROUTE TO 10PI11C DIANION
– Journal of the American Chemical Society
(2002)
99,
4756
(doi: 10.1021/ja00456a037)
Thermal isomerization of homoazocines
– Journal of the American Chemical Society
(2002)
100,
2909
(doi: 10.1021/ja00477a066)
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