Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation

EP Balskus, SV Ley

– Chemtracts

(2003)

16,

443

Microencapsulation of Osmium Tetroxide in Polyurea

SV Ley, C Ramarao, A-L Lee, N Østergaard, SC Smith, IM Shirley

– Organic Letters

(2002)

185

(doi: 10.1021/ol020225+)

Organic synthesis in a changing world

SV Ley, IR Baxendale

– Chemical record (New York, N.Y.)

(2002)

377

(doi: 10.1002/tcr.10033)

Benzotriazoles in solid-phase organic chemistry

M Donghi, J Habermann, SV Ley

– Chemtracts

(2002)

15,

751

Total synthesis of the cyclic peptide Argyrin B

SV Ley, A Priour

– European Journal of Organic Chemistry

(2002)

2002,

3995

(doi: 10.1002/1099-0690(200212)2002:23<3995::AID-EJOC3995>3.0.CO;2-P)

Application of ReactArray Robotics and Design of Experiments Techniques in Optimisation of Supported Reagent Chemistry

C Jamieson, MS Congreve, DF Emiabata-Smith, SV Ley, JJ Scicinski

– Organic Process Research & Development

(2002)

823

(doi: 10.1021/op010108e)

Butane‐2,3‐diacetals of Glyceraldehyde: A Stable Alternative to Glyceraldehyde Acetonide

P Michel, SV Ley

– Angew Chem Int Ed Engl

(2002)

41,

3898

(doi: 10.1002/1521-3773(20021018)41:20<3898::aid-anie3898>3.0.co;2-b)

Synthesis of the β2 Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents

RN Bream, SV Ley, PA Procopiou

– Organic Letters

(2002)

3793

(doi: 10.1021/o1020128g)

Highly selective entry to the azadirachtin skeleton via a Claisen rearrangement/radical cyclization sequence

T Durand-Reville, LB Gobbi, BL Gray, SV Ley, JS Scott

– Organic Letters

(2002)

3847

(doi: 10.1021/ol0201557)

Highly Diastereoselective Ketone Aldol Reactions of Butane-2,3-diacetal Desymmetrised Glycolic Acid

DJ Dixon, A Guarna, SV Ley, A Polara, F Rodriguez

– Synthesis

(2002)

2002,

1973

(doi: 10.1055/s-2002-34377)

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