Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Development of β-keto 1,3-dithianes:: Versatile platforms for organic synthesis.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U342
Development of an organic-catalyst mediated cyclopropanation reaction
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U361
Toward a total synthesis of thapsigargin.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U351
Organic-catalyst-mediated cyclopropanation reaction
– Angewandte Chemie (International ed. in English)
(2003)
42,
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
– Chemical communications (Cambridge, England)
(2003)
3,
678
(doi: 10.1039/b300074p)
A 2,3-butanedione protected chiral glycine equivalent--a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids.
– Chemical communications (Cambridge, England)
(2003)
468
(doi: 10.1039/b210673f)
Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks
– Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
– Chemical Communications
(2003)
3,
468
(doi: 10.1039/b210673f)
Development of new synthetic tools for the preparation of biologically active molecules
– CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129,
235
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
– Organic and Biomolecular Chemistry
(2003)
1,
3197
(doi: 10.1039/b306861g)
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