Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of the EF Fragment of Spongistatin 1

SV Ley, S Kawahara, MJ Gaunt, A Scolaro, S Yamanoi

Synlett

(2005)

2031

(doi: 10.1055/s-2005-871960)

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes

S Saaby, IR Baxendale, SV Ley

Organic & biomolecular chemistry

(2005)

3

3365

(doi: 10.1039/b509540a)

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis.

J Siu, IR Baxendale, RA Lewthwaite, SV Ley

Organic & Biomolecular Chemistry

(2005)

3

3140

(doi: 10.1039/b503778f)

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei

O Billker, MK Shaw, IW Jones, SV Ley, AJ Mordue, RE Sinden

The Journal of eukaryotic microbiology

(2005)

49

489

(doi: 10.1111/j.1550-7408.2002.tb00234.x)

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

S Saaby, KR Knudsen, M Ladlow, SV Ley

Chemical communications (Cambridge, England)

(2005)

2909

(doi: 10.1039/b504854k)

Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions (pg 1291, 2005)

S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley

SYNLETT

(2005)

1490

The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

IR Baxendale, SV Ley, M Martinelli

Tetrahedron

(2005)

61

5323

(doi: 10.1016/j.tet.2005.03.062)

Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents

IR Baxendale, A Lee, SV Ley

(2005)

133

(doi: 10.1002/9781444305548.ch6)

Total synthesis of antascomicin B.

DEA Brittain, CM Griffiths-Jones, MR Linder, MD Smith, C McCusker, JS Barlow, R Akiyama, K Yasuda, SV Ley

Angewandte Chemie International Edition

(2005)

44

2732

(doi: 10.1002/anie.200500174)

Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions

S Ley, S Lohmann, S Andrews, B Burke, M Smith, J Attfield, H Tanaka, K Kaneko

Synlett

(2005)

2005

1291

(doi: 10.1055/s-2005-865233)