Professor Steve Ley CBE FRS FMedSci | Page 42 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.

SP Andrews, MM Tait, M Ball, SV Ley

– Organic & biomolecular chemistry

(2007)

5,

1427

(doi: 10.1039/b702481a)

Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

KR Knudsen, J Holden, SV Ley, M Ladlow

– Advanced Synthesis & Catalysis

(2007)

349,

535

(doi: 10.1002/adsc.200600558)

Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

– Angewandte Chemie International Edition

(2007)

46,

2493

(doi: 10.1002/anie.200604688)

Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells

SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'

– Arch Insect Biochem Physiol

(2007)

64,

200

(doi: 10.1002/arch.20171)

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.

CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow

– Journal of Combinatorial Chemistry

(2007)

9,

422

(doi: 10.1021/cc060152b)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

– Angewandte Chemie International Edition

(2007)

46,

591

(doi: 10.1002/anie.200604053)

Total synthesis of thapsigargin, a potent SERCA pump inhibitor

M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley

– Organic letters

(2007)

9,

663

(doi: 10.1021/ol062947x)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

– Angew Chem Int Ed Engl

(2007)

46,

591

(doi: 10.1002/anie.200604053)

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development

IR Baxendale, RM Myers, DA Longbottom, SV Ley

(2007)

51

New avenues to efficient chemical synthesis

IR Baxendale, SV Ley

(2007)

151