Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Sulphuration of Electron-Rich Arenes with Sulphenamides and Aminosulphenyl Chlorides
Synthetic Communications
(2006)
10
291
(doi: 10.1080/00397918008062752)
Polymer-supported reagents and scavengers in synthesis
(2006)
3
791
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
Org Lett
(2006)
8
5231
(doi: 10.1021/ol061975c)
Stereocontrolled Total Synthesis of Bengazole A: A Marine Bisoxazole Natural Product Displaying Potent Antifungal Properties
Angew Chem Int Ed Engl
(2006)
45
6714
(doi: 10.1002/anie.200602050)
An enantioselective organocatalytic route to chiral 3,6-dihydropyridazines from aldehydes
Synlett
(2006)
2006
2548
(doi: 10.1055/s-2006-951486)
ORGN 141-Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2006)
232
Enantioselective Catalytic Intramolecular Cyclopropanation using Modified Cinchona Alkaloid Organocatalysts
Angew Chem Int Ed Engl
(2006)
45
6024
(doi: 10.1002/anie.200602129)
8,9,10,10a-Tetrahydro-6 H -tetrazolo[1,5- a ]pyrrolo[2,1- c ]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction
Synthesis
(2006)
2006
3215
(doi: 10.1055/s-2006-950219)
Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat™ 30NP
Beilstein Journal of Organic Chemistry
(2006)
2
15
(doi: 10.1186/1860-5397-2-15)
A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.
Chemical communications (Cambridge, England)
(2006)
3211
(doi: 10.1039/b606338a)
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